Abstract

This research was accomplished to identify the possibility of preventing cancer by Spirulina plantesis (SP) and curcumin nanoparticles (Cur-NPs) being natural substances in the EAC model. 110 male mice were split up randomly into group (I): healthy control; group (II): mice received SP; group (III): mice received Cur-NPs; group IV: mice administrated with both SP and Cur-NPs; group V: EAC group; group VI: SP Protective (Pr) group; group VII: SP Therapeutic (Tr) group; group VIII: Cur-NPs Pr group; group IX: Cur-NPs Tr group; group X: SP & Cur-NPs Pr group; group In comparison to the control group, the biochemical assays throughout this study exhibited an extremely significant rise in serum and hepatic MDA, ALT, and AST levels and a greatly marked drop in levels of TAC in the EAC group. In contrast, administration of Cur-Nps alone or combined with SP results in a significant reduction and improvement in their levels. The histological and immunohistochemical findings confirm the biochemical observations since the liver's histology and immunohistochemistry were improved by SP and Cur-NPs.