Abstract

Obesity is a common disease of dietary habits, with consequences such as heart disease and coronary artery disease. Cardiac disease is a serious problem because obesity alters the structure and function of the heart, causing heart failure and atrial fibrillation with a significant risk of mortality. We aspired to study the therapeutic effect of goldenberry against induced cardiac changes in obese rats. This study attempted to lessen the danger of cardiac disease in obese rats with extracts of the natural product known as goldenberry fruit with husk extract (GB) at two doses (200 and 400 mg/kg). There was a marked amelioration in the lipid profile and obesity hormones compared to the obese group. Administration of GB extract lowered cardiac markers, troponin I, creatine phosphokinase-MB (CK-MB), lactate dehydrogenase (LDH), cardiac tissue iron content, cardiac copper content, and malondialdehyde (MDA) in either blood plasma or heart tissue. Treatment with GB extracts decreased plasma levels of monocyte chemoattractant protein-1(MCP-1), resistin, Epithelial neutrophil-activating protein 78(ENA-78), tumour necrosis factor-alpha (TNF-α), interleukin 6 (IL-6, and C- reactive protein (CRP). The histopathology of the heart and aorta showed better repair of cardiomyocytes and fewer inflammatory cells. The results showed a positive correlation between body mass index (BMI) and MDA, MCP-1, CK-MB, and LDH. In conclusion, it appears that GB is useful in the treatment of cardiovascular disease in obese rats via reductions in oxidative stress, cardiac iron accumulation, insulin resistance, and inflammatory markers.

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