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Advancing Targeted Drug Delivery: The Role of Smart Polymers in Responsive Therapeutic Systems.

Article

Last updated: 01 Jan 2025

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-

Tags

Biochemistry

Abstract

Background:

Targeted drug delivery systems have transformed modern therapeutics by enabling precise delivery of drugs to specific sites, thereby reducing systemic toxicity. Smart polymers, with their unique ability to respond to environmental and biological stimuli, have emerged as innovative materials for developing responsive therapeutic systems. These polymers enable controlled drug release in response to triggers such as pH, temperature, enzymatic activity, and light, providing a significant advantage over conventional delivery systems. Despite their potential, challenges such as scalability, biocompatibility, and regulatory hurdles remain barriers to widespread clinical adoption.

Aim:

This paper aims to explore the role of smart polymers in advancing targeted drug delivery systems, with a focus on their responsive mechanisms, therapeutic applications, and future potential.

Methods:

The paper synthesizes findings from peer-reviewed studies and experimental data to evaluate the design, function, and clinical applications of smart polymers. Key responsive mechanisms and their implementation in polymer-based systems such as hydrogels, micelles, and nanocarriers are analyzed. Comparative evaluations with non-responsive delivery systems and case studies of clinical applications are included.

Results:

Smart polymers demonstrate significant improvements in targeted delivery, including enhanced drug bioavailability, reduced systemic toxicity, and improved therapeutic outcomes. Successful applications are highlighted in oncology, diabetes management, and neurodegenerative disease treatments. Case studies reveal promising clinical trial outcomes, but challenges in cost, production, and regulatory compliance remain.

Conclusion:

Smart polymers represent a transformative advancement in drug delivery, providing responsive, patient-specific therapeutic solutions. Addressing current challenges through interdisciplinary innovation and integration with emerging technologies such as nanotechnology and artificial intelligence could unlock their full potential, improving the efficacy and accessibility of future therapies.

DOI

10.21608/ejchem.2024.337880.10836

Keywords

Smart polymers, targeted drug delivery, responsive therapeutic systems, Controlled drug release, biocompatibility, Nanocarriers, Clinical applications

Authors

First Name

ABDULLAH IBRAHEM

Last Name

ALSHAMRANI

MiddleName

-

Affiliation

Ksa, Ministry of health, Jeddah First health cluster , Executive Managment Operation

Email

ficmahac@gmail.com

City

-

Orcid

-

First Name

ABDULMONEM YAHYA

Last Name

AL HADI

MiddleName

-

Affiliation

Ksa, Ministry of health

Email

anyt78@gmail.com

City

-

Orcid

-

First Name

Abdullah Hamad

Last Name

AlMutairi

MiddleName

-

Affiliation

Ksa, Ministry of health, Branch of the Ministry of health in Riyadh Region

Email

a-h-m-1396@hotmail.com

City

-

Orcid

-

First Name

Wafa Saleh

Last Name

ALkhweildy

MiddleName

-

Affiliation

Ksa, Ministry of health, Mansora primary health center

Email

wafasaleh80@hotmail.com

City

-

Orcid

-

First Name

Ghada Mansour

Last Name

Aldubiban

MiddleName

-

Affiliation

Ksa, Ministry of health, Faisaliah primary health center

Email

ghada711114@gmail.com

City

-

Orcid

-

First Name

Albader Mohammed

Last Name

Moafa

MiddleName

-

Affiliation

Ksa, Ministry of health, Prince Mohammed Bin Nasser Hospital

Email

albaderm@moh.gov.sa

City

-

Orcid

-

First Name

Fatimah Ali Mohammad

Last Name

Alshehri

MiddleName

-

Affiliation

Ksa, Ministry of health, Pharmacist in the public Health Department Riyadh

Email

nfm2011.fn@gmail.com

City

-

Orcid

-

First Name

Mohammed hussein

Last Name

Alnami

MiddleName

-

Affiliation

Ksa, Ministry of health, Riyadh

Email

alnmy719@gmail.com

City

-

Orcid

-

First Name

Ahmed Abdullah

Last Name

Alqarni

MiddleName

-

Affiliation

Ksa, Ministry of health, Al Amajiya Health Center

Email

hmadhaltbyshy240@gmail.com

City

-

Orcid

-

First Name

Zaki Hamad

Last Name

Ayoub

MiddleName

-

Affiliation

Ksa, Ministry of health, Jazan Health Complex

Email

zayoub@moh.gov.sa

City

-

Orcid

-

First Name

Mohammed Ali

Last Name

Banajia

MiddleName

-

Affiliation

Ksa, Ministry of health, Sabya General Hospital Jazan

Email

g.ziz@hotmail.com

City

-

Orcid

-

First Name

hameed nasser hameed

Last Name

Almutairi

MiddleName

-

Affiliation

Ksa, Ministry of health, king saud hospital

Email

hamd1948@hotmail.com

City

-

Orcid

-

First Name

FatimMohammed bin Ahmed

Last Name

Alnami

MiddleName

-

Affiliation

Ksa, Ministry of health, Branch of the Ministry of Health in Asir Region

Email

fmn1412@gmail.com

City

-

Orcid

-

First Name

Ahmed Mousa Ali

Last Name

Safhi

MiddleName

-

Affiliation

Ksa, Ministry of health, King Abdulaziz Hospital Jeddah

Email

ahmdainy6@hotmail.com

City

-

Orcid

-

First Name

Fahad Khalid Mohammed

Last Name

Aldossary

MiddleName

-

Affiliation

Ksa, Ministry of health, Hotat Bani Tamim Hospital

Email

fkaldawsari@moh.gov.sa

City

-

Orcid

-

Volume

67

Article Issue

13

Related Issue

46555

Issue Date

2024-12-01

Receive Date

2024-11-20

Publish Date

2024-12-01

Page Start

1,549

Page End

1,556

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 67_Issue 13_Pages 1549-1556.pdf

PDF . 657.9kB

Link

https://ejchem.journals.ekb.eg/article_396055.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=396055

Order

396,055

Type

Review Articles

Type Code

444

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Advancing Targeted Drug Delivery: The Role of Smart Polymers in Responsive Therapeutic Systems.

Details

Type

Article

Created At

30 Dec 2024