Background: Hypertension is a major public health issue worldwide, with high prevalence rates but low levels of awareness, treatment, and control. Despite its impact on cardiovascular health and its association with numerous risk factors, the management of hypertension remains suboptimal, particularly in low-resource settings. Emerging risk factors such as sugar intake, air and noise pollution, and low birth weight add complexity to the condition's pathophysiology. Effective hypertension management requires accurate diagnosis, improved treatment adherence, and tailored interventions across multiple healthcare sectors.

Aim: This article aims to examine the biochemical pathophysiology of hypertension and explore the role of nursing interventions in blood pressure regulation and treatment. It will also highlight the emerging risk factors, current challenges in hypertension management, and the importance of biomarkers in improving diagnosis and treatment.

Methods: A review of current literature on hypertension management was conducted, focusing on risk factors, challenges in diagnosis and control, and emerging strategies to improve treatment adherence. Relevant clinical guidelines and research on biomarkers were also analyzed to understand their role in hypertension care.

Results: The article identifies several emerging hypertension risk factors such as sugar intake, air pollution, and noise, which complicate treatment strategies. Challenges in hypertension management include inadequate health services, difficulty in diagnosing hypertension, and poor treatment adherence. Biomarkers, including genetic, molecular, and functional biomarkers, hold significant promise for early diagnosis, risk stratification, and personalized treatment strategies. The article also emphasizes the roles of patients, physicians, health authorities, nurses, and pharmacists in improving hypertension management.

Conclusion: The future of hypertension management lies in enhancing awareness, improving diagnostic accuracy, and integrating new biomarkers into clinical practice. National programs, targeted interventions, and financial coverage expansion are crucial to improving blood pressure control, particularly in resource-limited settings. Nurses, alongside physicians and other healthcare providers, have an essential role in patient education and adherence strategies. Effective integration of biomarkers into routine care could revolutionize hypertension management and lead to better long-term outcomes