Beta
ManageSearchChatDiscover
393509

Synthesis, Molecular Docking and Anticancer Activity of New Pyridyl-1,2,4-Triazole-Thioglycosides and Their Pyridyl-[1,2,4]triazolo[1,5-a]pyridine-Glycoside Analogues

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry

Abstract

Cancer remains a main threat for human life and requires intensive research for discovering and developing treatment strategies. The design and synthesis of novel functionalized and hybrid structures as candidates for anticancer activity investigation have been proven in the literature as an efficient approach for providing a variety of compounds. In the current work, new compounds of hybrid structures incorporating aryl- or heteroarylpyridine, 1,2,4-triazole, glycosyl moieties have been prepared via a stepwise pathway starting from simple available starting compounds. The anticancer activity against MCf-7, PC3 and A549 human cancer cell lines revealed that substituted 1,2,4-triazole-thiol based substituted pyridine structure and the N-glycosyl derivative of the 1,2,4-triazolopyridine compounds exhibited the most potent activities against MCF-7 and A549 cancer cells. Molecular docking into EGFR active site and showed good binding affinities via various modes.

DOI

10.21608/ejchem.2024.328404.10629

Keywords

Pyridine, 1, 2, 4-Triazole, glycosides, Anticancer activity, Molecular docking

Authors

First Name

Dania

Last Name

Alweet

MiddleName

-

Affiliation

Department of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia

Email

kareem.nh9@gmail.com

City

-

Orcid

-

First Name

Mohamed N.

Last Name

El-Bayaa

MiddleName

-

Affiliation

Department of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia, Department of Photochemistry, National Research Centre, Cairo 12622, Egypt.

Email

mnb6600@yahoo.com

City

-

Orcid

-

First Name

Sobhi

Last Name

Gomha

MiddleName

M.

Affiliation

Department of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah, 42351, Saudi Arabia

Email

s.m.gomha@gmail.com

City

-

Orcid

-

First Name

Fahad M.

Last Name

Almendrej

MiddleName

-

Affiliation

Department of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia

Email

f.alminderej@qu.edu.sa

City

-

Orcid

-

First Name

Eman S.

Last Name

Nossier

MiddleName

-

Affiliation

Department of Pharmaceutical Medicinal Chemistry and Drug Design, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt.

Email

emy28_s@hotmail.com

City

-

Orcid

-

First Name

Ahad

Last Name

El-Enazy

MiddleName

-

Affiliation

Department of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Wael A.

Last Name

El-Sayed

MiddleName

-

Affiliation

Department of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia

Email

w.shendy@qu.edu.sa

City

-

Orcid

-

Volume

67

Article Issue

13

Related Issue

46555

Issue Date

2024-12-01

Receive Date

2024-10-14

Publish Date

2024-12-01

Page Start

1,251

Page End

1,260

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 67_Issue 13_Pages 1251-1260.pdf

PDF . 1.2MB

Link

https://ejchem.journals.ekb.eg/article_393509.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=393509

Order

393,509

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Synthesis, Molecular Docking and Anticancer Activity of New Pyridyl-1,2,4-Triazole-Thioglycosides and Their Pyridyl-[1,2,4]triazolo[1,5-a]pyridine-Glycoside Analogues

Details

Type

Article

Created At

30 Dec 2024