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393510

Synthesis, Molecular Docking and Anticancer Activity of New Substituted Pyridine-1,2,3-Triazole Hybrid N-glycosides Via Click Chemistry

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Organic chemistry

Abstract

Cancer is still the most upsetting threat for human life and its fighting strategies have acquired intensive research. The design and synthesis of novel candidates for their possible potent anticancer activity has become a major objective in the drug anticancer discovery field. In the current research, new 1,2,3-triazole glycosides linked to substituted pyridine system were prepared vis click chemistry approach. A number of substituted acetylenic substrates incorporating varied structural features were applied for the click reaction. Various sugar moieties as acetylated glycopyranosyl forms provided the 1,4-disubstituted 1,2,3-triazole products possessing sugar, aryl- or heteroaryl substituents in the synthesized compounds. The 1,2,3-triazole glycoside 10 and its acetylenic precursor 6 possessing the biphenyl and thienyl rings in addition to the O-acetylated glucopyranosyl moiety showed the highest activity against A549, MCF7 and PC3 human cancer cell lines. Furthermore, the docking studies into EGFR and EGFR showing good binding modes with the protein active sites.

DOI

10.21608/ejchem.2024.326738.10597

Keywords

1,2,3-Triazole, Pyridine, eGFR, Cytotoxicity, Molecular docking

Authors

First Name

Nora S. A.

Last Name

Al-Sahaly

MiddleName

-

Affiliation

Department of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia

Email

sanaasoliman17@gmail.com

City

-

Orcid

-

First Name

Sewar

Last Name

Alghannay

MiddleName

-

Affiliation

Department of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia

Email

kareem.nh9@gmail.com

City

-

Orcid

-

First Name

Kaiss

Last Name

Aouadi

MiddleName

-

Affiliation

Department of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia

Email

k.aouadi@qu.edu.sa

City

-

Orcid

-

First Name

Mohamed N.

Last Name

El-Bayaa

MiddleName

-

Affiliation

Department of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia, Department of Photochemistry, National Research Centre, Cairo 12622, Egypt.

Email

mnb6600@yahoo.com

City

-

Orcid

-

First Name

Fahad

Last Name

Alminderej

MiddleName

M.

Affiliation

Department of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia

Email

f.alminderej@qu.edu.sa

City

-

Orcid

-

First Name

Sobhi

Last Name

Gomha

MiddleName

M.

Affiliation

Department of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah, 42351, Saudi Arabia

Email

s.m.gomha@gmail.com

City

-

Orcid

-

First Name

Hussien H.

Last Name

Elganzory

MiddleName

-

Affiliation

Department of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia

Email

hhsien@qu.edu.sa

City

-

Orcid

0000-0002-9426-5434

First Name

Wael

Last Name

El-Sayed

MiddleName

A.

Affiliation

Department of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia

Email

w.shendy@qu.edu.sa

City

-

Orcid

-

Volume

67

Article Issue

13

Related Issue

46555

Issue Date

2024-12-01

Receive Date

2024-10-08

Publish Date

2024-12-01

Page Start

1,221

Page End

1,233

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 67_Issue 13_Pages 1221-1233.pdf

PDF . 1.2MB

Link

https://ejchem.journals.ekb.eg/article_393510.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=393510

Order

393,510

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Synthesis, Molecular Docking and Anticancer Activity of New Substituted Pyridine-1,2,3-Triazole Hybrid N-glycosides Via Click Chemistry

Details

Type

Article

Created At

30 Dec 2024