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342945

Synthesis and Anticancer Activity Evaluation of New 1,2,4-Triazolyl-Quinazoline Hybrid Compounds and Their Pyrazolopyridine Analogs

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry

Abstract

1,2,4-Triazolopyrimidinen and their isosteric analogs such as triazolopyridine have possessed their interest in, the literature, due to the reported broad spectrum of bioactivities, one of which is the anticancer activity. In the current study, new functionalized 1,2,4-triazoles based substituted quinazoline system were prepared via multistep reactions starting from simple starting compounds. The reactions lead to the formation of the bi- and tricyclic 1,2,4-triazolopyridine and 1,2,4-triazolopyrimidine compounds from the S-alkylhydrazide, the ester and the hydrazine derivatives of the quinazoline system, respectively. The structures were characterized and confirmed by NMR, mass, and IR spectra. The anticancer activity revealed that several of the triazolopyrimidines based quinazoline structures especially those with theN-alkyl substitution in the quinazoline system were the most potent derivatives with results comparable to doxorubicin reference drug, the reference potent compound in the current investigation.

DOI

10.21608/ejchem.2024.257696.9043

Keywords

Quinazoline, triazolopyrimidine, triazolopyridine, Hydrazide, Anticancer

Authors

First Name

Adel A.-H.

Last Name

Abdel Rahman

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt

Email

ehabzayed1975@gmail.com

City

-

Orcid

-

First Name

Asmaa

Last Name

Sobhy

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt

Email

semsemschemist@gmail.com

City

-

Orcid

-

First Name

Mohamed A.

Last Name

Hawata

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt

Email

drmarwaabdelhady2015@yahoo.com

City

-

Orcid

-

First Name

Ehab

Last Name

Zayed

MiddleName

M.

Affiliation

Green Chemistry Department, National Research Centre, 33 El-Bohouth St. (former El Tahrir St.), P.O. 12622, Dokki, Giza, Egypt

Email

ehab_zayed2002@yahoo.com

City

Giza

Orcid

0000-0003-1245-8732

First Name

Hanem M.

Last Name

Awad

MiddleName

-

Affiliation

Tannic and Leather Materials Department, National Research Centre, 33 El-Bohouth St. (former El Tahrir St.), P.O. 12622, Dokki, Giza, Egypt

Email

drahmedhindy177@gmail.com

City

-

Orcid

-

First Name

Wael A.

Last Name

El-Sayed

MiddleName

-

Affiliation

Photochemistry Department, National Research Centre, Dokki, Giza, Egypt

Email

waelshendy@gmail.com

City

-

Orcid

0000-0002-8232-1830

Volume

67

Article Issue

13

Related Issue

46555

Issue Date

2024-12-01

Receive Date

2023-12-24

Publish Date

2024-12-01

Page Start

393

Page End

402

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 67_Issue 13_Pages 393-402.pdf

PDF . 415.9kB

Link

https://ejchem.journals.ekb.eg/article_342945.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=342945

Order

342,945

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Synthesis and Anticancer Activity Evaluation of New 1,2,4-Triazolyl-Quinazoline Hybrid Compounds and Their Pyrazolopyridine Analogs

Details

Type

Article

Created At

30 Dec 2024