A field experiment was carried out at the experimental Station of National Research Centre, Nubaria District, Behira Governorate, Egypt. During two seasons 2020/2021. To study the effect of NPK (19:19:19) with foliar spraying of potassium silicate and its effect on yield and nutrients uptake of wheat plants. Data showed the highest values in the chlorophyll content and growth parameters (plant height, spike length number of spikes/m2 and 1000-grain weight) from application of 30 kg fed-1 NPK (19:19:19) with potassium silicate at a rate of 100 ppm. The highest grain, straw and biological yield of wheat resulted from NPK treatments and foliar spraying with potassium silicate. The data also showed that a significant increase in the mentioned elements occurred with the use of NPK (19:19:19) fertilizers especially at a rate of 45 kg fed-1 as comparable to the control of grain and straw in both seasons respectively. A clear and noticeable effect on the protein and carbohydrate content of wheat grains and a clear decrease occurred with the comparison treatment. It led to an increase in micronutrient contents, with increases reaching as comparable to control for Fe, Zn, Mn and Cu in both seasons, respectively. Application of silicon resulted in a remarkable increase in wheat. This positive effect of potassium silicate application was particularly evident in wheat crops that were heavily fertilized with NPK grown under sandy soil conditions.