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338208

Facile One-Pot Strategy For Radiopreprationof Radioiodinated Phenylpiracetam As A New Highly Selective Radiotracer For Brainimaging

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Biochemistry

Abstract

The drug, phenylpiracetam, (PHPI, Iodophenylpiracetam ([131 I]-PHPI)) can prevent retrograde amnesia, and has anticonvulsant properties in models of animal was labeled using [I-131]with Chloramine-T(Ch-T) as an oxidizing agent to give a radiochemical yield of 98%. Many operators such as the amount of oxidizing agent, amount of substrate, pH, and reaction time, was systematically studied giving optimum conversion (98%) was obtained. Biodistribution studies indicate the[131I]PHPI tracer focuses on the target organ (brain) with a high percentage that is appropriate to use as a novel tracer for brain imaging. A labeled compound of [131I]-PHPImay be considered a highly selective radiotracer for brain tumor imaging compared withcommercially available radiotracers [99mTc] ECD and [99mTc] HMPAO.

DOI

10.21608/ejchem.2024.257311.9017

Keywords

Phenylpiracetam, I-131, Labeling, Brain Imaging, Biodistribution studies

Authors

First Name

M.

Last Name

Sanad

MiddleName

H.

Affiliation

Labeled Compounds Department, Hot Laboratories Center, Egyptian Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

Email

drsanad74@gmail.com

City

Cairo

Orcid

https://orcid.org/00

First Name

A. B.

Last Name

Farag

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, Giza, 12578 Egypt

Email

abfarag81@yahoo.com

City

-

Orcid

-

First Name

Gomaa N.

Last Name

Abdel-Rahman

MiddleName

-

Affiliation

Food Toxicology and Contaminants Department, National Research Centre, Dokki 12622, Cairo, Egypt

Email

gomaa.nrc@gmail.com

City

Giza

Orcid

0000-0002-6193-9033

First Name

Ahmed S. M.

Last Name

Fouzy

MiddleName

-

Affiliation

Food Toxicology and Contaminants Department, National Research Centre, Dokki 12622, Cairo, Egypt

Email

amoursy@hotmail.com

City

Egypt

Orcid

0000-0001-8178-713x

Volume

67

Article Issue

13

Related Issue

46555

Issue Date

2024-12-01

Receive Date

2023-12-22

Publish Date

2024-12-01

Page Start

189

Page End

198

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 67_Issue 13_Pages 189-198.pdf

PDF . 374.8kB

Link

https://ejchem.journals.ekb.eg/article_338208.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=338208

Order

338,208

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Facile One-Pot Strategy For Radiopreprationof Radioiodinated Phenylpiracetam As A New Highly Selective Radiotracer For Brainimaging

Details

Type

Article

Created At

30 Dec 2024