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339376

Neuroprotective Effect of Cardamom Essential Oil Encapsulated Nanoparticles and Swimming in Aluminum Induced Alzheimer’s disease in Rats

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Biochemistry

Abstract

As there is currently no cure for Alzheimer's disease (AD), considerable research is required to create plans to block the processes that cause memory loss. Functionalized nanomedicines that are nanoparticles contain central core structures that guarantee the encapsulation to offer protection and longer blood circulation. The purpose of this study was to investigate the neuroprotective effects of swimming exercise and nanoparticle-encapsulated cardamom oil (NCEO) on aluminum chloride-induced oxidative damage in experimental rats used as models for Alzheimer's disease. Experimental rats were induced for AD then groups were divided into different treatment groups; dopenzil, NCEO and swimming training. Different biochemical and pathological parameters were evaluated in both serum and muscles. Results showed and improvement in the concerned parameters with different treatment strategies. It can be concluded that both swimming and NCEO can be advised for AD patients.

DOI

10.21608/ejchem.2024.251449.8997

Keywords

Key words: Alzheimer’ s disease, swimming, nanoparticles encapsulated cardamom oil, Irisin, Aβ, PGC, 1α, FNDC5

Authors

First Name

Magdi

Last Name

Ashour

MiddleName

N.

Affiliation

Department of Medical Biochemistry, National Research Centre, Cairo, Egypt.

Email

magdiashour2009@yahoo.com

City

-

Orcid

-

First Name

Tahany

Last Name

Elias

MiddleName

R.

Affiliation

Department of Medical Biochemistry, National Research Centre, Cairo, Egypt.

Email

tahany_adel@hotmail.com

City

-

Orcid

-

First Name

Wafaa

Last Name

Rasheed

MiddleName

I

Affiliation

Department of Medical Biochemistry, National Research Centre, Cairo, Egypt.

Email

wafaa.rasheed@yahoo.com

City

-

Orcid

-

First Name

Safinaz

Last Name

El-Toukhya

MiddleName

E

Affiliation

Medical Biochemistry Department, Medical Research Division, National Research Centre, Giza, Egypt

Email

safi_toukhy@yahoo.com

City

-

Orcid

-

First Name

Eman

Last Name

Youness

MiddleName

R

Affiliation

Department of Medical Biochemistry, National Research Centre, Cairo, Egypt.

Email

er.youness@nrc.sci.eg

City

-

Orcid

-

First Name

Amany

Last Name

Sleem

MiddleName

A

Affiliation

Department of pharmacology, National Research Centre, Cairo, Egypt

Email

oe.el-sayed@nrc.ci.eg

City

-

Orcid

-

First Name

Manal mohamed

Last Name

Ramadan

MiddleName

-

Affiliation

Department of Chemistry of Flavour and Aroma, National Research Centre, Cairo, Egypt.

Email

manal.nrc88@gmail.com

City

cairo

Orcid

0000-0001-9908-5363

First Name

Khaled

Last Name

Mahmoud

MiddleName

Fahmy

Affiliation

Food Technology Dep., National Research Centre, Dokki, Egypt

Email

khaledfm69@yahoo.com

City

-

Orcid

0000-0001-7684-1605

First Name

Noha

Last Name

Yassen

MiddleName

N.

Affiliation

Department of Pathology, National Research Centre, Cairo, Egypt.

Email

noha.nazeeh@yahoo.com

City

-

Orcid

-

First Name

Mahmoud

Last Name

Abdel-Monem

MiddleName

A

Affiliation

Department of Medical Biochemistry, National Research Centre, Cairo, Egypt.

Email

mahmoud199018@gmail.com

City

-

Orcid

0000-0003-4540-1206

First Name

Omnia

Last Name

Aly

MiddleName

-

Affiliation

Department of Medical Biochemistry, National Research Centre, Cairo, Egypt.

Email

onnyashraf@live.com

City

-

Orcid

0000-0003-2754-6073

Volume

67

Article Issue

13

Related Issue

46555

Issue Date

2024-12-01

Receive Date

2023-12-18

Publish Date

2024-12-01

Page Start

37

Page End

52

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 67_Issue 13_Pages 37-52.pdf

PDF . 763.4kB

Link

https://ejchem.journals.ekb.eg/article_339376.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=339376

Order

339,376

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Neuroprotective Effect of Cardamom Essential Oil Encapsulated Nanoparticles and Swimming in Aluminum Induced Alzheimer’s disease in Rats

Details

Type

Article

Created At

30 Dec 2024