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319571

Gero-protective Impact of Astaxanthin on Experimental Model of Brain Aging: Biochemical and Molecular Study

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Last updated: 01 Jan 2025

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Abstract

Brain activity and multiple organ functions declined with aging. Although the complexity of brain aging process, releasing free radicals and inflammation were strongly linked to the disorder. Astaxanthin is a dietary carotenoid which exerts antioxidant and anti-inflammatory activities. We intended to estimate the protecting impact of Astaxanthin on aging caused by D-galactose. Forty male Wister rats were separated into 4 groups as follow: G1: (control) group:G2: (D-Gal) rats received D-Gal (300mg/kg,ip) ;G3 (D-Gal+Met) 4 h after D-Gal administration, rats received metformin (300 mg/kg, orally) , as reference drug group;G4 : (D-Gal+Asta) group: 4h after D-Gal treatment, rats received Astaxanthin (25 mg/kg , orally). Results showed that administering D-Gal caused brain aging manifested by significant (p<0.05) disturbance of antioxidant defense system, inflammatory biomarkers. Moreover, results of gene expression and histological assessment ensured biochemical findings. Astaxanthin supplementation promoted a remarkable significant (p<0.05) normalization in all parameters by triggering different brain mechanisms. In conclusion these results suggested that Astaxanthin modulates D-Gal induced brain-abnormalities associated with aging.

DOI

10.21608/ejchem.2023.232470.8520

Keywords

Astaxanthin, Brain Aging, D-galactose, Gero-protective

Authors

First Name

Hanadi M.

Last Name

Baeissa

MiddleName

-

Affiliation

Department of Biochemistry, College of Science ,University of Jeddah ,Jeddah, Saudi Arabia

Email

hmbaeissa@uj.edu.sa

City

Jeddah

Orcid

-

First Name

Aminah A.

Last Name

Barqawi

MiddleName

-

Affiliation

Department of Chemistry , College of Science ,Umm Al Qura University, Makkah Al-Mukarramah, Saudi Arabia

Email

aabbarqawi@uqu.edu.sa

City

-

Orcid

-

First Name

Manal A.

Last Name

Tashkandi

MiddleName

-

Affiliation

Department of Biochemistry, College of Science ,University of Jeddah ,Jeddah, Saudi Arabia

Email

matashkandi@uj.edu.sa

City

Jeddah

Orcid

-

First Name

Leena S.

Last Name

Alqahtani

MiddleName

-

Affiliation

Department of Biochemistry, College of Science ,University of Jeddah ,Jeddah, Saudi Arabia

Email

lsalqahtani@uj.edu.sa

City

Jeddah

Orcid

-

First Name

Reem

Last Name

Al-azragi

MiddleName

-

Affiliation

Department of Biochemistry, College of Science ,University of Jeddah ,Jeddah, Saudi Arabia

Email

rsalazragi@uj.edu.sa

City

Jeddah

Orcid

-

First Name

Neveen

Last Name

Salem

MiddleName

A.

Affiliation

Narcotics, Ergogenics, and Poisons Department , National Research Centre (NRC), Cairo, Egypt

Email

na.abdel-hameed@nrc.sci.eg

City

Egypt

Orcid

-

First Name

Rasha H.

Last Name

Hussein

MiddleName

-

Affiliation

Department of Biochemistry, College of Science ,University of Jeddah ,Jeddah, Saudi Arabia , Department of Biochemistry and Nutrition, Faculty of Women for Arts, Science and Education Ain Shams University , Cairo, Egypt.

Email

rhhussain@uj.edu.sa

City

-

Orcid

-

Volume

67

Article Issue

3

Related Issue

45192

Issue Date

2024-03-01

Receive Date

2023-08-28

Publish Date

2024-03-01

Page Start

297

Page End

307

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 67_Issue 3_Pages 297-307.pdf

PDF . 447.9kB

Link

https://ejchem.journals.ekb.eg/article_319571.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=319571

Order

319,571

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Gero-protective Impact of Astaxanthin on Experimental Model of Brain Aging: Biochemical and Molecular Study

Details

Type

Article

Created At

30 Dec 2024