311502

Melatonin the sleep hormone: could it be a future potential for the management of human obesity?

Article

Last updated: 01 Jan 2025

Subjects

-

Tags

Food Chemistry

Abstract

The pineal melatonin hormone is crucial for controlling the circadian cycle, mood swing, sleep quantity, quality and pattern. Postmenopausal females frequently complain of weight gain, body fat accumulation, increase waist circumference, and sleep disturbance with frequent nocturnal awakenings and difficulties initiating sleep. The aim of this study was to study the correlation between serum melatonin hormone level and response to diet therapy in postmenopausal Egyptian obese females. We prepared a food supplement in the form of crackles prepared from corn flour, wheat germ, flaxseed oil and enriched with clove and cinnamon powder. The chemical composition analysis of the crackles revealed that they were rich in healthy fat, fibre and protein. The subjects were classified into the groups according to the serum melatonin level; group (A) has serum melatonin value less than 5pg/ml, while group (B) has morning melatonin ≥ 5pg/ml. After six weeks of diet regimen protocol supplemented with daily consumption of 100 gram of prepared crackles by post menopausal obese women; there were statistical significance decrease in weight, BMI, %BF, waist and hip circumferences, total cholesterol level, and serum triglyceride. Moreover, the interleukin-6 as a marker of inflammation was decreased in both groups. There was statistical significant increase in serum HDL and total antioxidant capacity, while basal metabolic rate increased numerically without statistical significance. Studying the response to food supplements in weight reduction in relation to the morning serum melatonin level, we found that improvement was more in group with high melatonin level (≥ 5pg/ml) as regard measured parameters. The current study demonstrated that women whose melatonin level was high were more responsive to the diet therapy than women with low melatonin level. The results highlighting the potential benefit of exogenous melatonin during weight loss program in the postmenopausal obese women. It is promising to assess serum melatonin level in postmenopausal women to estimate the need to increase the intake of melatonin rich foods or melatonin tablets supplement in weight loss program.

DOI

10.21608/ejchem.2023.224080.8287

Keywords

Melatonin hormone, Menopause, weight loss, Body fat, metabolism, Functional foods

Authors

First Name

suzanne

Last Name

Fouad

MiddleName

-

Affiliation

Nutrition and Food Science Department. National Research Center Egypt

Email

suzannefouad6161@yahoo.com

City

Cairo

Orcid

0000-0001-9724-6135

First Name

Hend

Last Name

Essa

MiddleName

A

Affiliation

Nutrition and Food Science Department. National Research Center Egypt

Email

hendessabio@gmail.com

City

Giza

Orcid

-

First Name

Ahmed

Last Name

husseium

MiddleName

saeid

Affiliation

Food Technology Department, National Research Centre, Dokki, Giza, Egypt

Email

a-said22220@yahoo.com

City

-

Orcid

-

First Name

Nihad

Last Name

Ahmed

MiddleName

Hassan

Affiliation

Nutrition and Food Sciences, National Research Centre, Egypt

Email

nihadhassan94@yahoo.com

City

Cairo

Orcid

0000-0002-5593-6071

First Name

Salwa

Last Name

El Shebini

MiddleName

Mostafa

Affiliation

Nutrition and Food Sciences, National Research Centre, Egypt

Email

salwasheb@hotmail.com

City

Cairo

Orcid

0000-0002-3582-0311

Volume

67

Article Issue

2

Related Issue

44642

Issue Date

2024-02-01

Receive Date

2023-07-19

Publish Date

2024-02-01

Page Start

311

Page End

320

Print ISSN

0449-2285

Online ISSN

2357-0245

Link

https://ejchem.journals.ekb.eg/article_311502.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=311502

Order

311,502

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Melatonin the sleep hormone: could it be a future potential for the management of human obesity?

Details

Type

Article

Created At

30 Dec 2024