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311894

Development of Cloud Point Extraction for Preconcentration and Spectrophotometric Determination of Entecavir as Antiviral Drug in Pharmaceutical Formulations and Application to C

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Last updated: 01 Jan 2025

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Abstract

Entecavir (ENT), an antiviral medication, has been identified using two simple, sensitive, accurate, and precise spectrophotometric approaches that have been developed and verified. In order to produce a yellow-coloured Schiff's base product that can be detected at a maximum wavelength of 402 nm, ENT reacts with p-dimethylaminobenzaldehyde (p-DMAB) in an acidic solution. This reaction is the basis for method A. Under ideal conditions, the concentration range of 20-400 μg mL-1 agrees with Beer's law due to its excellent correlation coefficient (r2 = 0.9988) and low relative standard deviation (RSD% = 1.80). The method B approach uses cetyltrimethylammonium bromide (CTAB) and Triton X-114 as surfactants at a maximum wavelength of 415 nm to measure the amount of the yellow colour product using a cloud point extraction (CPE) methodology. Beer's law was seen to be obeyed in the concentration range of 0.1-3.0 μg mL-1, with a r2 value of 0.9995 and an RSD% of 1.50. The ideal reaction conditions include the molar ratio, solvent type, reagent concentration, and reaction time. The detection and quantification limits were calculated. With the regularly used excipients and additives, no interaction was noticed. The suggested techniques for measuring ENT in its pharmaceutical formulations were successfully applied, and the findings for pure ENT and commercial tablets were in good agreement with those from the reported approach.

DOI

10.21608/ejchem.2023.212041.7996

Keywords

Entecavir, p-Dimethylaminobenzaldehyde, Spectrophotometry, Cloud point extraction, dosage forms, Content uniformity

Authors

First Name

Ayman

Last Name

Gouda

MiddleName

A

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt

Email

aymangouda77@gmail.com

City

Zagazig

Orcid

0000-0001-5967-4585

First Name

Ragaa

Last Name

Shohaib

MiddleName

Elsheek

Affiliation

Professor of Analytical Chemistry, Faculty of Science, Elzakazik University, Egypt

Email

ragaaelsheikh@hotmail.com

City

-

Orcid

-

First Name

Mohannad

Last Name

Garoub

MiddleName

M

Affiliation

Occupational Health Department, Faculty of Public Health and Health Informatics, Umm AL-Qura University, Makkah, Saudi Arabia

Email

mmgaroub@uqu.edu.sa

City

Makkah

Orcid

-

First Name

Eman

Last Name

Fawzy

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt

Email

emanfawzy9989@gmail.com

City

Zagazig

Orcid

-

First Name

Moataz

Last Name

Mahmoud

MiddleName

S

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt

Email

mezooom53@gmail.com

City

Zagazig

Orcid

-

First Name

Ahmed

Last Name

Abdel Allem

MiddleName

F.

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt

Email

af2401024@gmail.com

City

Zagazig

Orcid

-

First Name

Ahmed

Last Name

El Sayed

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt

Email

a7medzekei@gmail.com

City

Zagazig

Orcid

-

First Name

Nesma

Last Name

Jumaa

MiddleName

M.

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt

Email

nessmagomaa521@gmail.com

City

Zagazig

Orcid

-

First Name

Alyaa

Last Name

Ibrahim

MiddleName

S.

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt

Email

alyaafares16@gmail.com

City

Zagazig

Orcid

-

Volume

67

Article Issue

2

Related Issue

44642

Issue Date

2024-02-01

Receive Date

2023-05-19

Publish Date

2024-02-01

Page Start

135

Page End

144

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 67_Issue 2_Pages 135-144.pdf

PDF . 549.5kB

Link

https://ejchem.journals.ekb.eg/article_311894.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=311894

Order

311,894

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Development of Cloud Point Extraction for Preconcentration and Spectrophotometric Determination of Entecavir as Antiviral Drug in Pharmaceutical Formulations and Application to C

Details

Type

Article

Created At

30 Dec 2024