One of the most significant Solanaceae genera is Cestrum L. which was perceived as a folk remedy., .Although the The genus Cestrum is recognized for its ornamental usage, in the oldest and newest studies, it turns out thisthe genus Cestrum has interesting isolated compounds and promising in-vivo and in-vitro biological activities. A number of unique metabolite structures were verified throughout the species represented as saponins, lignans, and flavonoids. Saponins were mainly …… steroidal saponins (spirostanol and …furostanol) …… Phenolic acids, aldehydes, phenyl propanoids, and alkaloids, in addition to non-polar components, which were determined to a much lesser extent. Those phytoconstituents that were characterized from different parts of the species by applying different solvents are crucial for various biological actions, including anti-microbial,anti -cancer,anti -viral,anti -inflammatory, and insecticidal effects. In this work, we haveThis work has an updated review of the phytochemical, pharmacological, and morphological characterizations.