Introduction: Children with Down syndrome have a physically inactive lifestyle which, in conjunction to poor nutritional selections cause pathophysiological development of cardiovascular diseases, osteoarthritis, diabetes mellitus, and obesity.

Aim of the study: Evaluating the efficacy of laser acupuncture as a mode of weight reduction in obese Down syndrome children.

Patients and methods: A prospective research trial in which 68 obese Down syndrome cases, ages ranged from 7 to 15 years had been recruited. IQ scoring, echocardiography, changes in eating, triglycerides, BMI and body composition had been performed for each patient. The cases were divided in two groups, each 34 cases. Group A had undergone laser acupuncture and diet regime. Group B was used as control with only diet regime.

Results: Body fat, BMI and serum triglycerides were more significantly decreased in laser group than the control group.

Conclusion: Laser acupuncture proved efficiency in management of obesity in Down syndrome children.