Mahogany trees were cultivated in new forests in Egypt for both their excellent timber quality and their role in climate change mitigation, one of the sustinable development goals. This work aimed to study four different species of mahogany seed oils MSOs [Kaya Ivorensis (KIO), Kaya Senegalensis (KSO), Swietenia Mahogni Lam oil (SMLO), and Swietenia Macrophylla King oil (SMKO)] as non-wood forest products. Their proximate analysis, fatty acid composition, bioactive component, oxidation stability antioxidant , and antimicrobial activity were studied. They showed a high oil content ranging from 48.81 to 62.48 %. Oils from (KIO) and (KSO) were characterized by higher amounts monounsaturated fatty acid, while (SMLO) and (SMKO) were found to have higher amounts of polyunsaturated fatty acids. KIO and KSO showed lower oxidizability value (cox) and hence higher stability while SMLO and SMKO showed higher total phenolic content and antioxidant activity. Concerning phytosterol composition β-sitosterol and campesterol were the most abundant phytosterols in all MSO. It also showed the presence of hexasiloxane in KSO and the presence of lanosta-8, 24-dien-3-one and lonstan-3β-ol, 11β, 18-epoxy-19-iodo-acetate in SMIO and SMKO. SMLO and SMKO showed considerable antimicrobial and antifungal activity. These results showed the possibility of using MSO in variable applications such as pharmaceutical, pesticide, and oleochemical industries, production of biodiesel as well as a sustainable alternative to edible oils for non-food purposes.