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302109

Enforcement of Ceftriaxone – PAM-18Na Polymer Nanoformula Versus Streptococcus pneumonia and Klebsiella pneumonia –as Pulmonary Pathogenic Bacteria

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Nanotechnology

Abstract

Ceftriaxone is one of the most often prescribed antibiotics for treating the majority of fatal bacterial infections. By forming a nanostructured complex between PAM-18Na polymer and common drugs, one can reduce drug consumption and lessen the adverse effects of the medicine. This study looked at the efficacy of a nanostructured formula containing Ceftriaxone-PAM-18Na for eradicating Streptococcus pneumonia and Klebsiella pneumonia. The dispersion method was applied to prepare the formula. The characterization of the polymer, ceftriaxone, as well as the formula, was done by XRD, FTIR, Zeta-sizer, and Zeta potential. Thermal characterization and morphology detection using a high-resolution transmission electron microscope were done for the formula. Compared to drug or polymer, antibacterial testing of the formula showed the greatest inhibition zones towards Gram-positive as well as Gram-negative pulmonary bacterial infections (18.0 ± 0.32 and 13.0 ± 0.51 mm, respectively). Ultrastructural examination revealed the dramatic effect of the synthesized formula on the structure of Streptococcus pneumonia and Klebsiella pneumonia. The synthesized formula had a cytotoxic concentration of CC50 = 960.12 ± 29.04 µg/mL when tested on MRC-5 mammalian cells, indicating its safety at clinically used concentrations. Our findings suggest that the PAM-18Na polymer can potentially improve Ceftriaxone's ability to eradicate pathogenic lung bacteria as a follow-up treatment option for resistant strains.

DOI

10.21608/ejchem.2023.187613.7457

Keywords

antimicrobial activity, nano-complex, Streptococcus pneumonia, Klebsiella pneumonia, ceftriaxone, PAM-18Na polymer

Authors

First Name

Asmaa

Last Name

Atef

MiddleName

-

Affiliation

Department of Biotechnology, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, Egypt, (postal code 62521)

Email

asmaaatefgabber@gmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Zanaty

MiddleName

I.

Affiliation

Department of Biotechnology, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, Egypt, (postal code 62521)

Email

zanaty012@yahoo.com

City

-

Orcid

-

First Name

Zienab

Last Name

Eldin

MiddleName

E.

Affiliation

Materials Science and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, 62511 Beni-Suef, Egypt, (postal code 62521)

Email

zeinab_reyd@yahoo.com

City

-

Orcid

-

First Name

Basma

Last Name

Amin

MiddleName

H.

Affiliation

The Regional Center for Mycology and Biotechnology (RCMB), Al-Azhar University, 11787, Nasr City, Cairo, Egypt

Email

basmafarag.18@azhar.edu.eg

City

-

Orcid

-

First Name

Ahmed

Last Name

Hamed

MiddleName

A.

Affiliation

National research center, Cairo Microbial Chemistry department, National Research Centre, 33 El-Buhouth Street,

Email

ahmedshalbio@gmail.com

City

Dokki

Orcid

0000-0002-9997-9284

First Name

Ahmed

Last Name

El-Gendy

MiddleName

O.

Affiliation

Faculty of Pharmacy, Beni-Suef University, Egypt

Email

ahmed.elgendy@pharm.bsu.edu.eg

City

Beni-suef

Orcid

0000-0002-0980-5185

First Name

Ahmed

Last Name

El-Shahawy

MiddleName

A. G.

Affiliation

Materials Science and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, 62511 Beni-Suef, Egypt (postal code 12827)

Email

ahmed.elshahawy@psas.bsu.edu.eg

City

-

Orcid

Orcid.org/0000-0002-4237-4268

Volume

66

Article Issue

13

Related Issue

43707

Issue Date

2023-12-01

Receive Date

2023-01-15

Publish Date

2023-12-01

Page Start

2,279

Page End

2,290

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 66_Issue 13_Pages 2279-2290.pdf

PDF . 1.8MB

Link

https://ejchem.journals.ekb.eg/article_302109.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=302109

Order

302,109

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Enforcement of Ceftriaxone – PAM-18Na Polymer Nanoformula Versus Streptococcus pneumonia and Klebsiella pneumonia –as Pulmonary Pathogenic Bacteria

Details

Type

Article

Created At

30 Dec 2024