The aim of the current study is to elaborate fire retarded thermoplastic polymer blends based on various blends. Neoprene rubber (CR) and polyvinyl chloride (PVC) blends are loaded with different concentrations of fillers such as sodium bentonite (SB), silica powder (SP), and magnesium hydroxide (Mg(OH)2), Talc, Al Silicate, Silicon dioxide and Kaolin. The general characteristics of the prepared blends were carried out using rheometric and physico-mechanical properties beside thermogravimetric analysis (TGA) and horizontal UL-94 (UL-94HB) measurements. The results showed that, it was found that, the prepared blends containing SB, SP and (Mg(OH)2) possessed the highest thermal stability values compared to CR/PVC blank blend. Furthermore, the thermal stability was increased with the increase of the concentrations of the loaded filler. Moreover, for further investigation, the CR/PVC blends with the ratio (75/25) loaded with SB, MH, Talc, Al Silicate, Silicon dioxide and Kaolin were studied. The examined blend samples exhibited high fire-retardant efficiency and reasonable rheological and mechanical properties. To sum up, the yielded enhanced properties of the blends can be considered as specific manifestations of a general scheme for a specific blend that can serve in multiple applications, particularly for fire retardant plastic products.