Fabrication of electrochemical sensors by screen printing technology represents a promising approach for fabrication of a planner electrochemical sensor. Herein, a novel memantine hydrochloride (MEM) potentiometric disposable sensor was constructed based on β-cyclodextrin-metal organic framework-multiwall carbon nanotube composite (β-CD-MOF-MWCNTs) as a selective recognition element for memantine molecule. Improved sensitivity was recorded within the MEM concentration ranged from 10-6 to 10-2 molL-1 with a theoretical Nernstian compliance value 60.5±0.9 mV decade -1 and a limit of detection value of 7.0×10 -7 molL-1. The fabricated disposable sensors showed long shelf lifetime (24 weeks) and fast response time (3s) which may be attributed to the incorporation of covalently bonded ionophore nanocomposite within the electrode matrix. The modified sensors were applied for determination of MEM in biological and pharmaceutical samples with high precision and accuracy. The developed sensors integrated with β-CD-MOF-MWCNTs offer approach for monitoring of the dissolution and degradation studies of memantine.