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327701

Computer modeling, docking, spectroscopic analysis, and antibacterial testing of metal chelates with dioxatetraaza ligand.

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Inorganic chemistry

Abstract

Our current efforts are aimed to synthesize new complexes of Co(II), Ni(II), Cu(II), Cr(III), Fe(III) and Zn(II) metal ions from heterocyclic dioxatetraaza ligand by condensation reaction of N1,N1'-(ethane-1,2-diyl)bis(ethane-1,2-diamine)with 2,2'-(ethane-1,2-diylbis(oxy))dibenzaldehyde to find out combating agent against microorganism diseases. Various physicochemical and spectroscopic techniques, including FT-IR, 1H and magnetic susceptibility, mass spectrometry, TGA, and others, were used to precisely characterize the synthesized compounds. These techniques suggested that the complexes' octahedral geometry was formed by epoxy oxygen atoms, azomethine nitrogen atomsof the dioxatetraaza ligand, and oxygen from the water molecules. The compounds' in vitro antibacterial activity against two bacterial and fungal pathogens was evaluated using the serial dilution method. Theoretical molecular docking was used to confirm these findings.

DOI

10.21608/ejchem.2023.238209.8653

Keywords

dioxatetraaza, physicochemical technique, Microorganism, antimicrobial activity, Transition metal chelates

Authors

First Name

Ehab

Last Name

Zayed

MiddleName

M.

Affiliation

Green Chemistry Department, National Research Centre,33 El-Bohouth St. (former El Tahrir St.), P.O. 12622, Dokki, Giza, Egypt

Email

ehab_zayed2002@yahoo.com

City

Giza

Orcid

0000-0003-1245-8732

First Name

Wael A.

Last Name

El-Sayed

MiddleName

-

Affiliation

Department of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia, Photochemistry Department, National Research Centre, Cairo 12622, Egypt

Email

waelshendy@gmail.com

City

-

Orcid

0000-0002-8232-1830

First Name

Hayam

Last Name

Abd El Salam

MiddleName

A.

Affiliation

Green Chemistry Department, National Research Centre,33 El-Bohouth St. (former El Tahrir St.), P.O. 12622, Dokki, Giza, Egypt

Email

yooma_nrc82@yahoo.com

City

Giza

Orcid

-

First Name

Gehad

Last Name

Mohamed

MiddleName

G.

Affiliation

Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt, 5Nanoscience Department, Basic and Applied Sciences Institute, Egypt-Japan University of Science and Technology, New Borg El Arab, Alexandria, 21934, Egypt

Email

ggenidymohamed@sci.cu.edu.eg

City

Giza

Orcid

0000-0002-1525-5271

Volume

66

Article Issue

13

Related Issue

43707

Issue Date

2023-12-01

Receive Date

2023-10-15

Publish Date

2023-12-01

Page Start

1,915

Page End

1,925

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 66_Issue 13_Pages 1915-1925.pdf

PDF . 1.1MB

Link

https://ejchem.journals.ekb.eg/article_327701.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=327701

Order

327,701

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Computer modeling, docking, spectroscopic analysis, and antibacterial testing of metal chelates with dioxatetraaza ligand.

Details

Type

Article

Created At

30 Dec 2024