In the frame of the strategic plan Egypt 2030 - a goal to create a supportive workplace environment. Indoor environment quality (IEQ) is an important factor to identify building's performance and comfort level. Key environmental parameters-related to IEQ of a multidisciplinary scientific research buildings were evaluated. Air biological (bacteria & fungi), chemical (PM, NO₂, SO₂, NH₃, HCOH & VOCs) and physical (T°C, RH%, air velocity, noise, lighting & electromagnetic radiation) parameters were measured indoor/outdoor. The measurements were performed using integrated sampling and real-time portable data instruments. The 75^th percentiles of airborne environmental bacteria, mesophilic bacteria and fungi were 5172 CFU/m³, 1294 CFU/m³ and 634 CFU/m³, respectively. Indoor/outdoor (I/O) ratios of VOCs, NH₃ and PM were ≥1. However, I/O ratios of HCOH, SO₂ and NO₂ were ≤ 1. Indoor temperature and relative humidity ranged between 17-35.6°C and 30-66.5%, respectively. Operative temperature averaged 23°C; it located within the comfort zone ≥20 −≤24°C in only ~ 43% of the investigated sites. Noise value exceeded the minimum acceptable level of 60 dBA in ~77.7% of sites. Lighting intensity did not achieve the minimum acceptable level of 300 lux in~ 48.5% of sites. The electric and magnetic strengths significantly fluctuated, ranging between 1-242 V/m and 0.5-437A/m, respectively. Thermal comfort, indoor air quality, noise and lighting are used to calculate IEQ index (I_IEQ). I_IEQ simulation revealed that the majority of the investigated sites had good IEQ conditions. I_IEQ helps identify ways to improve building environment.