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297573

Antitumor Potential and Possible Targets of Phenothiazine Derivatives: A Recent Review

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Pharmaceutical Chemistry

Abstract

The unique chemical characteristics of the phenothiazine ring system have been a major driving force for the development of various phenothiazine-based compounds with a huge spectrum of industrial and biological significance. Literature is ever continuously growing discussing the different roles and synthetic routes of phenothiazines. A huge body of novel and repurposed phenothiazines have been reported to have antitumor action. Unfortunately, only few reports discuss the proper mechanism of such action. In this review, a comprehensive overview of the identified targets and/or mechanism of action of recently reported antitumor phenothiazine derivatives are reviewed.

DOI

10.21608/ejchem.2023.199175.7715

Keywords

phenothiazine, antitumor, Molecular targets, Hybridization, repurposing

Authors

First Name

Mona

Last Name

Sarhan

MiddleName

O

Affiliation

Labelled Compounds Department, Hot Lab Center, Egyptian Atomic Energy Authority

Email

monasarhan@windowslive.com

City

-

Orcid

-

First Name

Nosaiba

Last Name

Fayadh

MiddleName

Attia

Affiliation

Pharmaceutical Chemistry department Faculty of pharmacy Helwan University Cairo Egypt

Email

nosaiba.fayad@pharm.helwan.edu.eg

City

-

Orcid

-

First Name

Radwan

Last Name

Elhaggar

MiddleName

-

Affiliation

Helwan University

Email

radwan_elhaggar@pharm.helwan.edu.eg

City

-

Orcid

0000-0002-3878-9890

First Name

Wafaa

Last Name

Zaghary

MiddleName

-

Affiliation

1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, P.O. Box 11795, Cairo, Egypt

Email

wzaghary@yahoo.com

City

-

Orcid

-

Volume

66

Article Issue

13

Related Issue

43707

Issue Date

2023-12-01

Receive Date

2023-03-11

Publish Date

2023-12-01

Page Start

1,001

Page End

1,014

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 66_Issue 13_Pages 1001-1014.pdf

PDF . 2.0MB

Link

https://ejchem.journals.ekb.eg/article_297573.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=297573

Order

297,573

Type

Review Articles

Type Code

444

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Antitumor Potential and Possible Targets of Phenothiazine Derivatives: A Recent Review

Details

Type

Article

Created At

30 Dec 2024