This work aimed to study the effect of some weed management practices associated with Giza 6 peanut variety cultivated during the summer season of 2021, on peanut oil characteristics. Also, their effect on the yield and growth parameters of peanut plant and the accompanied weeds was studied. The applied weed management techniques included hand hoeing and Clethodim herbicide treatment, using full and half rates, were done as a post-emergence compared to the untreated control. Foliar application of α-Tocopherol was done as a strategy of fighting stress accompanied to all other treatments and to control. Results showed that applying full rate of Clethodim herbicide + α-Tocopherol caused the most noteworthy diminishing in fresh and dry weights of peanut weeds. While, hoeing + α-Tocopherol gave the highest increasing percentage in most of peanut plant growth parameters as well as seed yield per feddan. The highest oil yield/feddan was also recorded for hoeing+ α-tocopherol treatment. Most of the chemical characteristics (peroxide, iodine and acid values) of peanut oils of the different treatments fulfilled the Codex standard characteristics for peanut oil and were better than that of the untreated control. Fatty acids composition of all peanut oil samples showed its characteristic profile with oleic: linoleic acid ratios ranged from 1.2 – 1.4 which gives peanut oil its healthy and stability advantage. Chloroplast pigments (total carotenoids and chlorophylls) and total Tocopherols contents were positively affected with the different treatments compared to the untreated control. These results assessed the protective action of the foliar application of α-Tocopherol compared to the untreated control. The peanut oil extracted from 50% herbicide + 30 % urea + α-Tocopherol treated seeds was found to have the most improved characteristics including fatty acids composition, chloroplast pigments and total Tocopherol contents. It can be concluded that weed management practices along with foliar application of α-Tocopherol are important measures needed to overcome the bad effects of weeds and proved to enhance the produced oil characteristics and the productivity of peanuts compared to the untreated control.