Ethylene vinyl acetate/ silicone rubber (EVA/ SR) polymer blends were prepared using the Brabender Plasticorder, then loaded with different ratios from curcumin nanoparticles and cured by using dicumyl peroxide (DCP). The blends were investigated by Fourier Transform Infrared (FTIR) spectroscopy, Scanning Electron Microscope (SEM), and Differential Scanning Calorimetry (DSC). The mechanical properties are increased with increasing in EVA content. 1-alkyl-3-methylimidazolium bromide [RMIM]Br Ionic Liquid (IL) and curcumin were selected as the hydrophilic and antibacterial for the green thermoplastic polymer blends. The combination of hydrophilic (IL) and antibacterial agent (curcumin) can kill the bacteria that found in contact with the surface of the polymers, and also avoid the adhesion of dead bacteria on the polymer surfaces. This study aims to produce, characterize, and assess the antimicrobial activity and cytotoxicity of polymer blends based on (EVA/ SR). The cytotoxicity of the prepared polymer blends towards the human tumor cell line BJ1 (normal skin fibroblast), indicated the safety of these products. On the other hand, the prepared polymer blends showed moderate antimicrobial potency towards the tested bacteria and fungi strains.