Genus Cordia has been well acknowledged in tropical and subtropical regions worldwide as traditional medicine, where its folk uses include uses in vital disorders. The current review considers the geographical distribution, macromorphological characters, nutritional properties, phytochemical profile and biological prospective survey of Cordia dichotoma (G. Forst.) and Cordia sebestena (L.), aiming to highlight the pharmacological significance of the two species. Considering their nutritional value, fruits and leaves of Cordia dichotoma are rich in nutritional constituents, while limited data described the nutritional importance of Cordia sebestena. A chemical survey of both species revealed many metabolites as phenolic acids, coumarins, flavonoids, terpenoids, sterols, volatile oils, carbohydrates, amino acids, fatty acids and others. The bioactivity studies of both species have been directed to possess potential antioxidant, antidiabetic, anticancer, anti-inflammatory, antipyretic, analgesic, anti-microbial, hypoglycemic, hypolipidemic and antiulcer activities. Meanwhile, antidepressant, antifertility, anti aging, anti-atherosclerotic, anti-anemic and diuretic activities were limited to C. dichotoma. On the other hand, anti-Alzheimer and larvicidal activities were limited to Cordia sebestena. There are fewer reported studies on C. sebestena, in spite of its important folk uses. Thus, this review draws attention to further biological research on C. sebestena to discover its medicinal uses.