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Effect Of High Fat Diet Induced Metabolic Syndrome And Treatment With Insulin Like Growth Factor 1 On Biochemical And Immunohistochemical Parameters Related To Neuronal Functions

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Last updated: 01 Jan 2025

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Pharmaceutical Chemistry

Abstract

The prevalence of metabolic syndrome (MetS) makes type 2 diabetes mellitus and its consequences more common in communities. Dysfunctions of the nervous system has negative implications on the lives of affected individuals and their families. This study aimed to elucidate the possible role of MetS and treatment with in insulin like growth factor 1 (IGF-1) on some biochemical and immunohistochemical parameters related to neuronal functions in adult male albino rats. For this purpose, fifty adult male albino rats were recruited and divided into five groups. (1) control group, (2) MetS group (induced by high fat diet for eight weeks), (3) MetS group treated with IGF-1 for six weeks started two weeks before induction of MetS, (4) MetS group treated with IGF-1 for six weeks started with induction of MetS, (5) MetS group treated with IGF-1 for six weeks started two weeks after starting induction of MetS. Fasting blood glucose (FBG), insulin, lipid profile, glucagon like peptide 1 (GLP1), tumor necrosis factor-α (TNF-α) and adiponectin levels were measured in the serum whereas malonaldehyde, glutathione peroxidase (GPx), brain derived neurotrophic factor (BDNF), synapsin 1 and sortilin were measured in brain tissue homogenate. Histo pathological and immunohistochemical studies for B cell lymphoma 2 (BCL2) and glial fibrillary acidic protein (GFAP) were also done. The results showed that induction of MetS caused hyperglycemia, hyperinsulinemia, dyslipidemia, elevation of the oxidant marker MDA and the proinflamatory TNF-α whereas the anti-oxidant GPx and the anti-infalimatory adiponectin were elevated. BDNF and the anti-apoptotic BCL2 were reduced whereas synapsin 1, sortilin and the astrocytes proliferation marker GFAP were increased. Treatment with IGF-1 was associated with improvement in all these parameters. It could be concluded that MetS is associated with reduction in neuronal protective factors and enhancement of factors which impair neuronal functions and structures. These effects may underlie the pathogenesis of cognitive dysfunction associating MetS. By antagonizing such effects of MetS, IGF-1 may be helpful in managing MetS and associated cognitive dysfunction.

DOI

10.21608/ejchem.2023.191284.7550

Keywords

Metabolic syndrome, Cognitive dysfunction, Insulin like growth factor 1, brain derived neurotrophic factor, synapsin 1, Sortilin

Authors

First Name

Asmaa Fathy

Last Name

Yousuf

MiddleName

-

Affiliation

Medical physiology department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt

Email

asmaafathy.medg@azhar.edu.eg

City

Cairo

Orcid

0000-0002-1925-0398

First Name

Shimaa

Last Name

Elshora

MiddleName

Zakaria

Affiliation

Histology department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt

Email

shimaa.zakaria@azhar.edu.eg

City

Cairo

Orcid

0000-0002-0605

First Name

Mohamed

Last Name

Abdallah

MiddleName

Gaber

Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Email

dr.mohamed.gaber@azhar.edu.eg

City

-

Orcid

0000-0003-3936-4883

First Name

Noura

Last Name

Elmongy

MiddleName

F.

Affiliation

Medical physiology department, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt

Email

dr.nourafathy20@domazhermedicine.edu.eg

City

Damietta

Orcid

0000-0002-3908-4497

First Name

Heba

Last Name

Aboelsoud

MiddleName

Abdelnaser

Affiliation

Anatomy and Embryology department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt

Email

hebaabdelnaser.medg@azhar.edu.eg

City

Cairo

Orcid

0000-0002-7736-414X

First Name

Hala

Last Name

Mosallam

MiddleName

Hamed

Affiliation

Anatomy and Embryology department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt

Email

hala.hamed@azhar.edu.eg

City

Cairo

Orcid

-

First Name

Ashraf

Last Name

Algendy

MiddleName

Mohamed Mohamed

Affiliation

Department of Medical Physiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Email

drashrafalgendy1010@gmail.com

City

-

Orcid

0000-0003-3776-4357

First Name

Abd El-Lateef

Last Name

Abd El-Lateef

MiddleName

Saeed

Affiliation

Department of Medical Pharmacology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Email

abdelatif.said35@yahoo.com

City

-

Orcid

0000-0002-7484-9272

First Name

Abdou

Last Name

El-Sharkawy

MiddleName

Mohammed

Affiliation

Department of Medical Pharmacology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Email

abdouelsharkawy@gmail.com

City

Cairo

Orcid

-

First Name

Nora

Last Name

Seliem

MiddleName

-

Affiliation

Biochemistry department, faculty of medicine for girls, Al-Azhar University, Cairo, Egypt

Email

noraseliem30@azhar.edu.eg

City

Cairo

Orcid

0000-0001-9541

First Name

Rehab

Last Name

El shahat

MiddleName

Mohamed

Affiliation

Pharmacology department, Faculty of medicine for girls, Al- Azhar University, Cairo, Egypt

Email

rehab@azhar.edu.eg

City

Cairo

Orcid

0000-0001-9569-0056

First Name

Ahmad

Last Name

Alkot

MiddleName

Mohammad Farag

Affiliation

Medical Physiology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Email

dr.ahmadalkot@gmail.com

City

-

Orcid

0000-0002-4551-5310

Volume

66

Article Issue

13

Related Issue

43707

Issue Date

2023-12-01

Receive Date

2023-02-02

Publish Date

2023-12-01

Page Start

389

Page End

400

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 66_Issue 13_Pages 389-400.pdf

PDF . 1.9MB

Link

https://ejchem.journals.ekb.eg/article_288032.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=288032

Order

288,032

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Effect Of High Fat Diet Induced Metabolic Syndrome And Treatment With Insulin Like Growth Factor 1 On Biochemical And Immunohistochemical Parameters Related To Neuronal Functions

Details

Type

Article

Created At

30 Dec 2024