A novel, easy, quick and precise spectrophotometric technique has been established for the evaluation of catecholamines (methyldopa, levodopa, dopamine and carbidopa) in pure forms and in their pharmaceutical preparations, this technique is focused on the reaction of these catecholamines as n donor with pyromellitic dianhydride as π acceptor in the presence of sodium hydroxide. The maximum absorptions at 300, 302, 301, and 298 nm for methyldopa, levodopa, dopamine and carbidopa respectively. In a concentration range of Beer's law was obeyed 0.2-40, 0.2-40, 0.2-50 and 0.2-100 µg.mL-1 with molar absorptivities 9921.2975, 8982.8334, 6430.8797 and 5022.7469 L/mol.cm for the catecholamines in turn. The accuracy range between 98.843% and 100.891% and RSD% is less than 2% for the above catecholamines respectively. The detection limit (LOD) was 0.0518, 0.0581, 0.0638 and 0.0579 µg.mL-1 and limit of quantification (LOQ) was 0.1571, 0.1762, 0.1935 and 0.1756 µg.mL-1 for the above catecholamines in turn. The suggested approach was successfully used to the analysis of catecholamines in pure as well as medications formulation with a good average recovery.