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Unexpected Products of the Reaction of Cyanoacetylhydrazones of Aryl/heteryl Ketones with Hydrazine: A New Route to Aryl/Heteryl Hydrazones, X-ray Structure, and In vitro Anti-pr

Article

Last updated: 01 Jan 2025

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Tags

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Abstract

A new unexpected synthetic non-catalytic method for the synthesis of novel heteryl hydrazones for base-modification of nucleoside analogs has been developed. Characterizations of the products have been performed using NMR spectroscopy and single crystal x-ray diffraction analysis. Further in vitro anti-proliferative potency of the compounds against NCI 60 cell lines has been estimated. The results indicate anti-cancer activity by the compounds against several of the cancer cell lines.

DOI

10.21608/ejchem.2023.197330.7682

Keywords

Crystal, X-ray, hydrazons, heteryl hydrazons, in vitro anti-proliferative activity

Authors

First Name

Reham A.

Last Name

Mohamed-Ezzat

MiddleName

-

Affiliation

Chemistry of Natural & Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Center, Cairo, 12622, Egypt

Email

reham_amgad_2010@yahoo.com

City

Cairo

Orcid

0000-0001-6388-5350

First Name

Benson M.

Last Name

Kariuki

MiddleName

-

Affiliation

School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, UK

Email

kariukib@cardiff.ac.uk

City

Cardiff

Orcid

0002-8658-3897

First Name

Galal H.

Last Name

Elgemeie

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Helwan University, Cairo, 11795, Egypt.

Email

elgemeie@yahoo.com

City

-

Orcid

0000-0003-3268-5975

Volume

66

Article Issue

13

Related Issue

43707

Issue Date

2023-12-01

Receive Date

2023-03-04

Publish Date

2023-12-01

Page Start

225

Page End

239

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 66_Issue 13_Pages 225-239.pdf

PDF . 2.6MB

Link

https://ejchem.journals.ekb.eg/article_296496.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=296496

Order

296,496

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Unexpected Products of the Reaction of Cyanoacetylhydrazones of Aryl/heteryl Ketones with Hydrazine: A New Route to Aryl/Heteryl Hydrazones, X-ray Structure, and In vitro Anti-pr

Details

Type

Article

Created At

30 Dec 2024