There have been studies on the possible use of capsaicin as a treatment for cancer, and some of these studies have explored the use of capsaicin-based drug delivery systems. Nanocarrier-based drug delivery systems have been designed for the release of capsaicin for the prevention and treatment of cancer. Recent advances have been made in the field of nanomedicine and nanotechnology, which have the potential to aid in the treatment of various diseases. The use of capsaicin in conjunction with traditional chemotherapy agents or radiation treatment has been explored as a promising strategy for cancer treatment. Some studies have found that sustained release drug delivery systems based on capsaicin have shown efficacy in cancer chemotherapy. However, additional study is required to fully understand the potential of capsaicin-based delivery systems for cancer treatment.