The effect of honey fortified with bee venom was assessed on patients complaining of fatigue and exhaustion. 123 women aged 32- 35 years participated as volunteers in the study, Sixty-two subjects participated in group (A), they consumed 30 ml clover honey fortified with bee venom with a mean age of 32.86 ± 12.07 years while sixty-one volunteers enrolled in group (B) as a control group, they consumed 30 ml clover honey with a mean age of 34.75 ± 12.26years. After two months of dietary supplements consumption, subjects in group (A) showed a statistically significant improvement in the calculated fatigue scores, the anti-inflammatory marker (IL-10), catalase enzyme, MDA and SOD (p < 0.05). While participants in group (B) consuming clover honey unfortified showed an improvement in the MDA serum level and FSS fatigue score (p < 0.05). Furthermore, the haemoglobin level increased numerically in both group but without statistical significance difference (p > 0.05), moreover, there was no effect on fasting blood sugar level in both groups (p > 0.05).

Conclusion: clover honey fortified with bee venom can alleviate fatigue and exhaustion.