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287870

The Effect of Processing Physical Parameters on the Mechanical, Microstructure, and Porosity of Gelatin-HA Scaffolds Produced by Freeze-Drying Technique for Biomedical Application

Article

Last updated: 01 Jan 2025

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Tags

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Abstract

Scaffolds made for bone tissue engineering are the most preferred way of addressing the complex challenges of bone defect healing. Natural polymers are extensively explored in this area because of their features (Biodegradability, biocompatibility, natural abundance, and high processing ability). Hydroxyapatite (HA) has been employed as a restorative material because of its bone compatibility following implantation. However, the brittleness of HA, which limits its usage, is typical of ceramic materials. As a result, a gelatin layer was applied to the surface of the HA scaffold to provide hardness. This study uses the Freeze-Dryer technique to create porous HA scaffolds doped with gelatin. The scaffolds' microstructures, porosity, and mechanical characteristics were studied. XRD and FTIR measurements prove the presence of HA in the prepared gelatin-HA Scaffolds. The mechanical properties of the studied scaffolds have high value after adding chitosan and starch to the prepared gelatin-HA scaffolds. The porosity of the composite scaffolds was enhanced depending on the strategies used to create them and the cross-linked agent added to the manufactured scaffolds. The results confirm the excellent agreement between the porosity and mechanical properties of the scaffolds, in addition to the excellent agreement between gelatin and hydroxyapatite.

DOI

10.21608/ejchem.2022.147414.6392

Keywords

gelatin, Hydroxyapatite, Scaffolds, Bone tissue engineering

Authors

First Name

Aya

Last Name

Elhelw

MiddleName

-

Affiliation

Faculty of Science, Physics Department, Mansoura University, 35516 Mansoura, Egypt.

Email

ayakadri@mans.edu.eg

City

AL-MANSURAH

Orcid

-

First Name

Mohamed

Last Name

El-Henawy

MiddleName

-

Affiliation

Faculty of Science, Physics Department, Mansoura University, 35516 Mansoura, Egypt.

Email

melhenawy@mans.edu.eg

City

El Mansoura

Orcid

-

First Name

Raafat

Last Name

Mandour

MiddleName

-

Affiliation

Toxicology Department, emergency hospital, Faculty of Medicine, Mansoura University, 35516 Mansoura, Egypt.

Email

raafat_mandour@hotmail.com

City

-

Orcid

-

First Name

Maher

Last Name

El-Tonsy

MiddleName

-

Affiliation

Faculty of Science, Physics Department,, Mansoura University, 35516 Mansoura, Egypt.

Email

el_tonsy@yahoo.co.uk

City

AL-MANSURAH

Orcid

-

Volume

66

Article Issue

11

Related Issue

43443

Issue Date

2023-11-01

Receive Date

2022-06-27

Publish Date

2023-11-01

Page Start

43

Page End

52

Print ISSN

0449-2285

Online ISSN

2357-0245

Link

https://ejchem.journals.ekb.eg/article_287870.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=287870

Order

287,870

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

The Effect of Processing Physical Parameters on the Mechanical, Microstructure, and Porosity of Gelatin-HA Scaffolds Produced by Freeze-Drying Technique for Biomedical Applications

Details

Type

Article

Created At

30 Dec 2024