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284133

Synthesis, Antitumor, Antimicrobial and Anti-Hepatities B Activities of New 3-(4-chlorophenyl)-N-(p-tolyl)acrylamide Chalcone Derivatives

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry

Abstract

New substituted pyrimidine, pyrazole, pyridine and pyrrole derivatives were synthesized from an unsaturated arylacetylmine key derivative via cyclization reaction with the suitable corresponding reagent and their structures were characterized by elemental and spectral analyses. The anticancer, antimicrobial and anti-Hepatities B activity of the synthesized compounds were studied against a panel of cells and microbes. The results showed moderate to high activities for most of the tested compounds.

DOI

10.21608/ejchem.2023.172380.7187

Keywords

Pyrimidine, Pyridine, pyrazole, Antimicrobial, antitumor, Antiviral, anti-Hepatities B

Authors

First Name

Ibrahim

Last Name

Nassar

MiddleName

F.

Affiliation

Department of Chemistry, Faculty of Specific Education, Ain Shams University, Abassia, Cairo, Egypt

Email

dr.ibrahim.nassar@sedu.asu.edu.eg

City

cairo

Orcid

0000-0002-8123-2238

First Name

Adel A. H.

Last Name

Abdel Rahman

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Menofia University, Shbien El-Kom, Egypt

Email

adelnassar63@yahoo.com

City

-

Orcid

0000-0003-3319-8191

First Name

Heba A.

Last Name

Adel Khalek

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Menofia University, Shbien El-Kom, Egypt

Email

hebaahmed@yahoo.com

City

-

Orcid

-

First Name

Afrah

Last Name

Sharaf

MiddleName

-

Affiliation

Department of Chemistry, College of Science, Jazan University, Kingdom of Saudi Arabia

Email

afrahmohamed77@yahoo.com.ph

City

-

Orcid

-

First Name

Wael A.

Last Name

El-Sayed

MiddleName

-

Affiliation

Department of Chemistry, College of Science, Qassim University, Buraydah, Saudi Arabia, Photochemistry Department, National Research Centre, Dokki, Cairo, Egypt

Email

waelshendy@gmail.com

City

-

Orcid

0000-0002-8232-1830

Volume

66

Article Issue

10

Related Issue

43169

Issue Date

2023-10-01

Receive Date

2022-11-13

Publish Date

2023-10-01

Page Start

621

Page End

637

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 66_Issue 10_Pages 621-637.pdf

PDF . 277.7kB

Link

https://ejchem.journals.ekb.eg/article_284133.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=284133

Order

284,133

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Synthesis, Antitumor, Antimicrobial and Anti-Hepatities B Activities of New 3-(4-chlorophenyl)-N-(p-tolyl)acrylamide Chalcone Derivatives

Details

Type

Article

Created At

30 Dec 2024