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280871

Antimicrobial Benzofuran Derivatives and Chemosystematic Significance of Senecio glaucus L. (Asteraceae)

Article

Last updated: 01 Jan 2025

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Tags

Pharmaceutical Chemistry

Abstract

Phytochemical investigation of methylenechloride/methanol (1:1) extract of the air-dried aerial parts of Senecio glaucus L. afforded three benzofuran derivatives (1-3); 1-(6-hydroxy-2-(prop-1-en-2-yl) benzofuran-5-yl) ethanone, 1-1'-(6-hydroxybenzofuran-2,5-diyl) diethanone, and 1-1'-(6-methoxybenzofuran-2,5-diyl) diethanone. The crude extract and isolated compounds (1-3) were screened against S. aureus and E. coli and also against C. albicans and A. flavus. Compound 1 and 2 were more potent than 3 against S. aureus and E. coli, however, the crude extract and isolated compounds (1-3) showed weak antifungal activity against C. albicans and A. flavus. In addition, a biosynthetic pathway of isolated compounds (1-3) was proposed, as well as the chemotaxonomic significance of the reported benzofuran and furanoeremophilane derivatives from S. glaucus compared to those isolated from other Senecio species was also studied.

DOI

10.21608/ejchem.2023.168069.7076

Keywords

Senecio glaucus, Chemosystematic significance, Biosynthetic pathway, Antimicrobial Benzofuran derivatives

Authors

First Name

Taha A.

Last Name

Hussien

MiddleName

-

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Sphinx University, Assiut, Egypt,

Email

-

City

-

Orcid

-

First Name

Dina A.

Last Name

El-Amir

MiddleName

-

Affiliation

Department of Botany, Faculty of Science, Aswan University, Egypt,

Email

-

City

-

Orcid

-

First Name

Usama A. A.

Last Name

Radwan

MiddleName

-

Affiliation

Department of Botany, Faculty of Science, Aswan University, Egypt,

Email

-

City

-

Orcid

-

First Name

Magdi A.

Last Name

El-Sayed

MiddleName

-

Affiliation

Department of Botany, Faculty of Science, Aswan University, Egypt, , Department of Biological Science, Molecular Biotechnology program, Field of Advanced Basic Sciences, Galala University, New Galala City, Egypt,

Email

-

City

-

Orcid

-

First Name

Abou El-Hamd H.

Last Name

Mohamed

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Aswan University, Egypt

Email

abouhassan68@yahoo.com

City

-

Orcid

-

First Name

Hussein

Last Name

El-Damarany

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Aswan University, Egypt

Email

-

City

-

Orcid

-

Volume

66

Article Issue

10

Related Issue

43169

Issue Date

2023-10-01

Receive Date

2022-10-10

Publish Date

2023-10-01

Page Start

575

Page End

583

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 66_Issue 10_Pages 575-583.pdf

PDF . 573.9kB

Link

https://ejchem.journals.ekb.eg/article_280871.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=280871

Order

280,871

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Antimicrobial Benzofuran Derivatives and Chemosystematic Significance of Senecio glaucus L. (Asteraceae)

Details

Type

Article

Created At

30 Dec 2024