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Study of the Effect of Stevia With or Without Metformin on Streptozotocin – Nicotinamide Induced Diabetes in Adult Male Albino Rats

Article

Last updated: 01 Jan 2025

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Tags

Pharmaceutical Chemistry

Abstract

There is growing evidence that detects a pathological vicious circle relationship between complications of diabetes mellitus (DM) and oxidative stress as well as abnormal inflammatory response. This study aimed to elucidate possible effects of stevia, with or without metformin, on glycemic indices, redox state, and inflammatory state in DM induced by streptozotocin and nicotinamide in adult male albino rats. For this purpose, fifty adult male albino rats were equally divided into five groups: group 1 (control), group 2 (diabetic), group 3 (diabetic metformin-treated), group 4 (diabetic stevia-treated), and group 5 (metformin and stevia-treated). The experiment continued for four weeks. Then fasting blood glucose (FBG), insulin, Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), malondialdehyde (MDA), catalase, tumor necrosis factor-α (TNF-α), and interleukin-10 (IL-10) were measured. The results of the study showed that metformin as well as stevia either as a monotherapy or combination significantly improved glycemic profile in parallel with balancing redox status and ameliorating inflammatory response in diabetic adult male albino rats. Co-administration of stevia with metformin appeared to have a synergistic effect. It could be concluded that stevia increases metformin's anti-inflammatory and antioxidant properties. and can be used as a complementary therapy for the management of oxidative stress and inflammatory insult in DM.

DOI

10.21608/ejchem.2023.181921.7353

Keywords

diabetes, Streptozotosin, nicotinamide, Metformin, Stevia

Authors

First Name

Ashraf

Last Name

Algendy

MiddleName

M. M.

Affiliation

Department of Medical Physiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Email

drashrafalgendy1010@gmail.com

City

-

Orcid

0000-0003-3776-4357

First Name

Eman

Last Name

Mahmoud

MiddleName

S.

Affiliation

Histology Department, Faculty of Medicine (Girls), Al-Azhar University, Cairo, Egypt.

Email

emansaid7374@gmail.com

City

-

Orcid

0000-0002-4830-050x

First Name

Abir

Last Name

Mohamed

MiddleName

Khalil

Affiliation

Zoology Department, Faculty of Science (Girl's), Al-Azhar University, Cairo, Egypt.

Email

abirkhalil09@azhar.edu.eg

City

-

Orcid

0000-0002-2818-5030

First Name

Nageh

Last Name

Gabr

MiddleName

Mabrouk

Affiliation

Department of Medical Physiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Email

gabrnageh@yahoo.com

City

-

Orcid

0000-0002-3399-5265

First Name

Abd El-Lateef S.

Last Name

Abd El-Lateef

MiddleName

-

Affiliation

Department of Medical Pharmacology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Email

abdelatif.said35@yahoo.com

City

-

Orcid

0000-0002-7484-9272

First Name

Mohamed

Last Name

Abdallah

MiddleName

Gaber

Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Email

dr.mohamed.gaber@azhar.edu.eg

City

-

Orcid

0000-0003-3936-4883

First Name

Mahmoud

Last Name

Gewaily

MiddleName

S.

Affiliation

Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt

Email

msgewaily@vet.kfs.edu.eg

City

-

Orcid

0000-0002-3650-7896

First Name

Ahmad Mohammad Farag

Last Name

Alkot

MiddleName

-

Affiliation

Department of Medical Physiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Email

dr.ahmadalkot@gmail.com

City

-

Orcid

0000-0002-4551-5310

Volume

66

Article Issue

10

Related Issue

43169

Issue Date

2023-10-01

Receive Date

2022-12-19

Publish Date

2023-10-01

Page Start

303

Page End

315

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 66_Issue 10_Pages 303-315.pdf

PDF . 3.1MB

Link

https://ejchem.journals.ekb.eg/article_283621.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=283621

Order

283,621

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Study of the Effect of Stevia With or Without Metformin on Streptozotocin – Nicotinamide Induced Diabetes in Adult Male Albino Rats

Details

Type

Article

Created At

30 Dec 2024