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275189

Phytochemical Composition and Anti-SARS-CoV-2 Activity of Leaves Methanolic Extract of Silybum marianum.

Article

Last updated: 01 Jan 2025

Subjects

-

Tags

Organic chemistry

Abstract

In line with the global interest and demand in finding sustainable ways to counteract the emerging viral pandemics, our study highlights the unique composition and anti- SARS-CoV-2 activity of a barely used and studied part of the famous medicinal plant Silybum marianum (L.) Gaertn. Various chromatographic and spectroscopic techniques used in the process of isolation and structure elucidation led to the identification of nine flavonoids for the first time from the methanolic leaves extract. Among them, the aglycone acacetin (2) was isolated for the first time from the genus. The antiviral activity of the extract against SARS-CoV-2 main protease showed considerable activity with half-maximal inhibitory and cytotoxic concentrations; IC50=80.5 µg/ml and CC50=576.5 µg/ml, respectively indicating a relatively high selectivity; SI = 7.1.

DOI

10.21608/ejchem.2022.176808.7239

Keywords

Silybum marianum, Asteracea, Medicinal plant, leaves, Flavonoids, anti-viral activity

Authors

First Name

Rasha

Last Name

Elatif

MiddleName

Abdel

Affiliation

Phytochemistry and Plant Systematics Department, National Research Centre, El-Dokki, Cairo Egypt.

Email

rasharefaat38@yahoo.com

City

Cairo

Orcid

-

First Name

Reham

Last Name

ElSharawy

MiddleName

-

Affiliation

Department of Phytochemistry and Plant Systematics, Pharmaceutical and Drug Industries Research institute, National research center, Cairo, Egypt

Email

reham_elsharawy@hotmail.com

City

Cairo

Orcid

0000-0003-2926-5283

First Name

Ragaa

Last Name

Mansour

MiddleName

Ali

Affiliation

National Research center, DOKKI, Cairo, Egypt.

Email

ragaamansour42@hotmail.com

City

Cairo

Orcid

-

First Name

mohamed

Last Name

El Ansari

MiddleName

Amin

Affiliation

national research center

Email

ansarialaa@hotmail.com

City

-

Orcid

-

First Name

Manal

Last Name

Shabana

MiddleName

Hassan

Affiliation

phytochemistry and plant systematic departement,National Research Centre

Email

shabanamhs61@hotmail.com

City

Cairo

Orcid

-

First Name

Mahmed

Last Name

sharaf

MiddleName

-

Affiliation

National Research center, DOKKI, Cairo, Egypt.

Email

sharafali1589@gmail.com

City

Cairo

Orcid

0000-0002-3975-2301

Volume

66

Article Issue

9

Related Issue

43167

Issue Date

2023-09-01

Receive Date

2022-11-27

Publish Date

2023-09-01

Page Start

473

Page End

478

Print ISSN

0449-2285

Online ISSN

2357-0245

Link

https://ejchem.journals.ekb.eg/article_275189.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=275189

Order

275,189

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Phytochemical Composition and Anti-SARS-CoV-2 Activity of Leaves Methanolic Extract of Silybum marianum.

Details

Type

Article

Created At

30 Dec 2024