Beta
ManageSearchChatDiscover
278153

Cytotoxic activity of some benzo[4,5]imidazo[1,2-a]pyrimidine derivatives against the human cancer cell lines HepG2 and MCF-7

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Biochemistry

Abstract

Different benzo[4,5]imidazo[1,2-a]pyrimidine derivatives were synthesized in high purity and yields with short reaction times by the reaction of 2-aminobenzimidazole, aldehydes and active carbonyl compounds in the presence of Silica sulfuric acid/ethylene glycol (SSA/EG) as a catalyst. Cytotoxicity of the synthesized benzo[4,5]imidazo[1,2-a]pyrimidine derivatives 1-6 was carried out against the two human cancer cell lines, hepatocellular carcinoma (HepG2) and breast carcinoma (MCF-7) as well as Vero cells (normal cells).

DOI

10.21608/ejchem.2023.173878.7209

Keywords

Benzo[4,5]imidazo[1,2-a]pyrimidine, Cytotoxicity, human cancer cell lines, Hepatocellular carcinoma, Breast carcinoma

Authors

First Name

Wahid

Last Name

Basyouni

MiddleName

-

Affiliation

National Research Centre

Email

w_basyouni2002@yahoo.com

City

-

Orcid

0000-0001-5482-9250

First Name

Samir

Last Name

Abbas

MiddleName

Youssef

Affiliation

Organometalic and Organometalliod Chemistry Department, National Research Centre

Email

samiryoussef98@yahoo.com

City

12622

Orcid

-

First Name

Khairy

Last Name

El-bayouki

MiddleName

A.M

Affiliation

Organometallic chemistry Department, National research centre

Email

bayouki_2012@yahoo.com

City

-

Orcid

0000-0001-8099-6685

First Name

Mohamed

Last Name

El-kady

MiddleName

Y.

Affiliation

Ain Shams university

Email

melkady@ainshams.edu.eg

City

cairo

Orcid

-

First Name

Nagwa

Last Name

Abdelazeem

MiddleName

M.

Affiliation

Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt.

Email

nagwamorad@yahoo.com

City

-

Orcid

https://orcid.org/00

First Name

Reham

Last Name

Dawood

MiddleName

-

Affiliation

Microbial Biotechnology Department, National Research Centre, Dokki, Cairo, Egypt

Email

rmhaemd@hotmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Shemis

MiddleName

A.

Affiliation

Biochemistry and Molecular Biology Department, Theodor Bilharz Research Institute,Cairo, Egypt.

Email

mohamedshemis@gmx.com

City

-

Orcid

-

Volume

66

Article Issue

9

Related Issue

43167

Issue Date

2023-09-01

Receive Date

2022-11-21

Publish Date

2023-09-01

Page Start

237

Page End

243

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 66_Issue 9_Pages 237-243.pdf

PDF . 854.8kB

Link

https://ejchem.journals.ekb.eg/article_278153.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=278153

Order

278,153

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Cytotoxic activity of some benzo[4,5]imidazo[1,2-a]pyrimidine derivatives against the human cancer cell lines HepG2 and MCF-7

Details

Type

Article

Created At

30 Dec 2024