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274383

Simple Green RP-UPLC.MethodForThe Analysis Of Ganciclovir In Its Bulk Form And Pharmaceutical Preparations

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Analytical chemistry

Abstract

Abstract

A green simple validated reversed phase ultra -. performance liquid chromatographic method was developed for the analysis of ganciclovir in both bulk and two different dosage.forms. The optimum separation was reached using AcclaimTM RSLC.120 C18…column..(2.1.x.100.mm,.2.2.µm) at 30°C using the mobile phase composed of methanol (60%) and 20 mM phosphate buffer,. pH (4.00) 40%; at 0.5 mL/min. flow rate. The measurement took place at 253 nm using a photodiode array detector. The method was linear at concentration ranged from 20.00 to 300.00 µg/mL. The limit of detection and the limit of quantification were 7.00.µg/mL and 20.00 µg/mL, respectively. The range for the percentage relative standard deviation of intra.-.day was 0.38 to 1.10 %, while for inter-day precisions was 0.56 to 2.08 %, respectively. The method was accurate with percentage recovery ranged from 98.71 to 101.02 % with percentage relative standard…deviation ranged from 0.38 to 1.10 %. The method was favorably applied for determining of ganciclovir in bulk, pharmaceutical tablet and gel preparation. The greenness of the method was assessed by the analytical. eco-scale system and it was found to be eco-friendly.

DOI

10.21608/ejchem.2022.171668.7134

Keywords

Anti-viral, Ultra-performance liquid chromatography, validation, Green chemistry, Valcyte® tablets, Ganvir® eye gel

Authors

First Name

Semirna

Last Name

Danial

MiddleName

-

Affiliation

The Center for Drug Research and Development (CDRD), Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt

Email

semirna178602@bue.edu.eg

City

Cairo

Orcid

-

First Name

Fatma

Last Name

Gamal

MiddleName

-

Affiliation

The Center for Drug Research and Development (CDRD), Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt

Email

fatma173407@bue.edu.eg

City

Cairo

Orcid

-

First Name

Nada

Last Name

Saad

MiddleName

-

Affiliation

The Center for Drug Research and Development (CDRD), Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt

Email

nada171239@bue.edu.eg

City

Cairo

Orcid

-

First Name

Hala

Last Name

Hamdy

MiddleName

-

Affiliation

The Center for Drug Research and Development (CDRD), Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt

Email

hala167547@bue.edu.eg

City

Cairo

Orcid

-

First Name

Ghada

Last Name

Adel

MiddleName

-

Affiliation

The Center for Drug Research and Development (CDRD), Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt

Email

ghada174968@bue.edu.eg

City

Cairo

Orcid

-

First Name

Mahmoud

Last Name

Elnahas

MiddleName

-

Affiliation

The Center for Drug Research and Development (CDRD), Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.

Email

mahnmoud174481@bue.edu.eg

City

Cairo

Orcid

-

First Name

Fady

Last Name

Wael

MiddleName

-

Affiliation

The Center for Drug Research and Development (CDRD), Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt

Email

fady178607@bue.edu.eg

City

Cairo

Orcid

-

First Name

Sohair

Last Name

Aboelghar

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, The British University in Egypt (BUE), Cairo, Egypt

Email

sohair.aboelghar@bue.edu.eg

City

Cairo

Orcid

-

First Name

Nada

Last Name

Hesham

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, The British University in Egypt (BUE), Cairo, Egypt

Email

nada.hesham@bue.edu.eg

City

Cairo

Orcid

-

First Name

Mohamed

Last Name

Tarek

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, The British University in Egypt (BUE), Cairo, Egypt.

Email

mohamed.tarek@bue.edu.eg

City

Cairo

Orcid

0000-0002-1741-0263

First Name

Hebatallah

Last Name

Wagdy

MiddleName

A

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, The British university in Egypt (BUE), Cairo, Egypt

Email

hebatallah.wagdy@bue.edu.eg

City

Cairo

Orcid

0000-0003-1975-7700

Volume

66

Article Issue

9

Related Issue

43167

Issue Date

2023-09-01

Receive Date

2022-10-30

Publish Date

2023-09-01

Page Start

133

Page End

143

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 66_Issue 9_Pages 133-143.pdf

PDF . 1.3MB

Link

https://ejchem.journals.ekb.eg/article_274383.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=274383

Order

274,383

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Simple Green RP-UPLC.MethodForThe Analysis Of Ganciclovir In Its Bulk Form And Pharmaceutical Preparations

Details

Type

Article

Created At

30 Dec 2024