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273265

Facile Synthesis, Inhibition of VEGFR-2, Anticancer activity, Molecular Dynamics Simulation and Target Identification of Some New Pyrano thiazine derivatives

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Organic chemistry

Abstract

A new series of )2-amino-4-(substituted)-4,10-dihydrobenzo[b]pyrano[2,3-e][1,4]thiazine-3-carbonitrile( 3(a, b) was synthesized by the reaction of 2-(substituted) malononitrile with 2H-benzo[b][1,4]thiazin-3(4H)-one as a key starting material, )2-amino-4-(substituted)-4,10-dihydrobenzo[b]pyrano[2,3-e][1,4]thiazine-3-carbonitrile( 3(a, b) reacted with some reagents, namely, formic acid, sulphuric acid, thiosemicarbazide, ethyl acetoacetate, triethyl orthoformate, carbon disulphide, diethylmalonate, malononitrile, phosphoryl chloride , and acetic anhydride to produce compounds 4(a,b), 5(a,b), 6(a,b), 8(a,b), 9(a,b), 10(a,b),11(a,b),14(a,b),15(a,b), and 18(a,b) some of newly synthesized compounds were studied and screened for their in vitro anticancer activity. Moreover, molecular dynamics simulation and target identification studies were conducted to support the findings .All the newly synthesized compounds were structurally confirmed by various modern analytical methods (IR, 1H NMR and MS).

DOI

10.21608/ejchem.2022.173057.7167

Keywords

pyrano thiazine. VEGFR-2, Anticancer, Molecular dynamics simulation

Authors

First Name

Walaa Salah

Last Name

Elserwy

MiddleName

-

Affiliation

Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo, Egypt, 12622.

Email

walaasalah16@yahoo.com

City

-

Orcid

0000-0002-0400-4637

First Name

Neama

Last Name

Mohammed

MiddleName

-

Affiliation

Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo, Egypt, 12622.

Email

neamanrc@yahoo.com

City

-

Orcid

0000-0003-1221-9926

First Name

Weam Salah

Last Name

Elserwy

MiddleName

-

Affiliation

Department Of Microbial and Natural Products chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo, Egypt, 12622.

Email

awab_13@yahoo.com

City

-

Orcid

0000-0003-1757-1742

First Name

Mohamed

Last Name

Abdallah

MiddleName

-

Affiliation

Atos Pharma, Elkatyba Land, Belbis, ElSharkya 44621, Egypt.

Email

dr_mohamed211@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

El-Rashedy

MiddleName

-

Affiliation

Department Of Microbial and Natural Products chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo, Egypt, 12622.

Email

ahmedelrashedy45@gmail.com

City

Durban

Orcid

0000-0003-3899-5376

Volume

66

Article Issue

8

Related Issue

42250

Issue Date

2023-08-01

Receive Date

2022-11-09

Publish Date

2023-08-01

Page Start

467

Page End

483

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 66_Issue 8_Pages 467-483.pdf

PDF . 1.7MB

Link

https://ejchem.journals.ekb.eg/article_273265.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=273265

Order

273,265

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Facile Synthesis, Inhibition of VEGFR-2, Anticancer activity, Molecular Dynamics Simulation and Target Identification of Some New Pyrano thiazine derivatives

Details

Type

Article

Created At

30 Dec 2024