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271831

Antioxidant and antimicrobial efficiency of curcumin nanoparticles against pathogenic microorganisms

Article

Last updated: 01 Jan 2025

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Tags

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Abstract

Curcumin (Cur) is a pivotal compound widely used in pharmaceutical and medical applications such as antioxidant, antimicrobial, anticancer, and anti-inflammatory. However, some limitations faced its application in different purposes owing to its insolubility, low bioavailability, and fast degradation. These limitations can be overcome by the formulation of Cur nanoparticles (Cur-NPs) to boost its bioactivity and enhance its solubility. This study aimed to synthesize and characterize Cur-NPs and evaluate the antioxidant activity and antimicrobial efficiency against different pathogenic microorganisms. Cur-NPs were prepared, characterized and the antimicrobial efficiency was evaluated against E. coli, S. typhimurium, and Y. enterocolitica (Gram-negative), S. aureus, B. cereus (Gram-positive), and the pathogenic fungi (Aspergillus niger, A flavus, Penicillium expansum, and Candida albicans). The synthesized Cur-NPs showed a rounded shape with 44 ± 8 nm average size and 43 ± 4 mV ξ-potential. Cur-NPs showed potent antioxidant (IC50 of 1550 µg/ml) and antimicrobial properties against the tested bacteria and fungi in a dose-dependent manner. It could be concluded that Cur-NPs are a promising candidate to be used as an antimicrobial in food preservation, or medical and pharmaceutical applications to replace antibiotics.

DOI

10.21608/ejchem.2022.160916.6926

Keywords

curcumin nanoparticles, antioxidant, Antibacterial, Antifungal, Antimicrobial

Authors

First Name

Amira

Last Name

Sehim

MiddleName

E.

Affiliation

Botany and Microbiology Dept, Faculty of Science; Benha University, Benha, Egypt

Email

amira.alsayed@fsc.bu.edu.eg

City

-

Orcid

-

First Name

Rasha

Last Name

Abdel-Ghafar

MiddleName

Y.

Affiliation

Botany and Microbiology Dept, Faculty of Science; Benha University, Benha, Egypt

Email

rasha.mohamed@fsc.bu.edu.eg

City

-

Orcid

-

First Name

zeinab

Last Name

Hamza

MiddleName

khaaled

Affiliation

Food Toxicology & Contaminants Dept., National Research Centre, Cairo, Egypt

Email

zeinabkh_85@yahoo.com

City

cairo

Orcid

0000-0001-6002-4598

First Name

Aziza

Last Name

El-Nekeety

MiddleName

A.

Affiliation

Food Toxicology & Contaminants Dept., National Research Center

Email

azaegjp@yahoo.com

City

-

Orcid

-

First Name

Mossad

Last Name

ِAbdel-Wahhab

MiddleName

ِAttia

Affiliation

Department of Food Toxicology & Contaminants. National Research Center ·

Email

mosaad_abdelwahhab@yahoo.com

City

-

Orcid

0000-0002-7174-3341

Volume

66

Article Issue

8

Related Issue

42250

Issue Date

2023-08-01

Receive Date

2022-10-03

Publish Date

2023-08-01

Page Start

383

Page End

392

Print ISSN

0449-2285

Online ISSN

2357-0245

Link

https://ejchem.journals.ekb.eg/article_271831.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=271831

Order

271,831

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Antioxidant and antimicrobial efficiency of curcumin nanoparticles against pathogenic microorganisms

Details

Type

Article

Created At

30 Dec 2024