A new preparation method was reported to synthesize graphene GO - carboxymethyl cellulose CMC and hydroxyapatite HA (GO/CMC/HA). This new bio-nanocomposite was studied to control the loading and release cycle of amoxicillin drugs. The drug loading kinetics and release were studied with respect to the concentration of CMC of the drug carrier while keeping the concentration of GO and HA constant. The targeted delivery of amoxicillin was aimed at using these ternary nanocomposites. The evidence of functional groups and phase purity was analyzed using FTIR spectroscopy and X-ray diffraction techniques. The morphological features were studied using scanning electron microscopy. The thermal property of the developed materials was evaluated by thermogravimetric analysis (TGA). The elastic and storage modulus (G' and G'') as well as the complex viscosity (*) were recorded for the various concentration of CMC through rheological measurements. The efficiency of the drug delivery was studied using a diffusion mechanism. All the physico-chemical characterizations and rhological studies showed the efficacious synthesis of the new bio- nanocomposites GO/CMC/HA, through in situ precipitation and presents a good candidate to control the drug release applications.