As a result of climate changes, plants are exposed to the problem of drought. Trial conducted on increasing plant tolerance to drought and improving the quality of its yield throughout the use of phosphate and iron fertilizer. A field experiment was conducted at the Research and Production Station of the National Research Centre, Nubaria region, Behira Governorate, Egypt to test the effects of phosphorus (0, 25, 50, 100 Kg fed-1) and ferrous sulphate (0, 50, 100 and 150 ppm) on the phytochemical composition of sesame seeds resulted from plants grown under sufficient and deficit irrigation regimens. Increasing phosphorus rates was affiliated with increasing the macro and micronutrient, oil, protein, carbohydrates %. `Also, Antioxidant compounds (Phenol and flavonoids) and total DPPH radical scavenging of sesame seeds were increased(P<0.05) significantly .Under both irrigation systems, the application of phosphorus (100 Kg fed-1) with Fe sulphate (150 ppm) induced the most significant increase in all previous parameters . It can be concluded that, the use of triple phosphate fertilizer and spraying sesame plants with iron at 100 Kg/fed plus 150 ppm Iron improved the chemical components and consequently the nutritive value of sesame seeds due to increasing plant tolerant to water deficit