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275921

New Glycosylated Flavone and Anthraquinone from Cassia notabilis Randell.: Antidiabetic, Anti-inflammatory and Analgesic Activity Evaluation

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Pharmaceutical Chemistry

Abstract

The phytochemical investigation of the leaves of Cassia notabilis Randell. revealed the isolation of two new glycosides, identified as 6-methoxyapigenin-4`-methyl ether 7- O-α-L-rhamnopyranoside-8-C-β-D-glucopyranoside (1) and 1,7,8-trihydroxyanthraquinone 3-O-β -D-glucopyranoside (7), along with apigenin 7-O- β-D-glucpyranosyl-(1→6)-β-D-glucopyranoside (2), acacetin 7- O-α-L-rhamnopyranoside (3), luteolin 7-O- β-D-glucpyranosyl-(1→6)-β-D-glucopyranoside (4), luteolin 7-O- β-D-glucpyranoside (5), diosmetin 7- O-α-L-rhamnopyranoside (6). The structures of the isolated compounds were established by chromatographic and spectroscopic evidences. Pharmacological studies showed that the three doses of 70% aqueous methanolic extract of C. notabilis leaves (125, 250 and 500 mg/kg) have antidiabetic, analgesic, anti-inflammatory and antioxidant activity.

DOI

10.21608/ejchem.2022.178935.7271

Keywords

Cassia notabilis, Flavonoids, antidiabetic, Anti-inflammatory, analgesic, antioxidant

Authors

First Name

Mahmoud

Last Name

Nassar

MiddleName

Ibrahim

Affiliation

Natural product chemistry, pharmaceutical institute, NRC.

Email

mnassar_eg@yahoo.com

City

Cairo

Orcid

0000-0002-2493-4663

First Name

Rehab

Last Name

Fikry

MiddleName

-

Affiliation

Natural Compounds Chemistry Department, National Research Centre, Dokki, Giza, Egypt

Email

rehabfikrytaher@gmail.com

City

Cairo

Orcid

0000-0001-9321-1971

First Name

Sayed

Last Name

El-Toumy

MiddleName

Abdel Hamid

Affiliation

Chemistry of Tannins Department, National Research Centre

Email

sayedeltomy@yahoo.com

City

Cairo

Orcid

https://orcid.org/00

First Name

Seham

Last Name

El Hawary

MiddleName

Salah Eldin

Affiliation

Pharmacognosy Department, Faculty of Pharmacy, Cairo University

Email

seham.elhawary@yahoo.com

City

Cairo

Orcid

0000-0002-6823

First Name

Rania

Last Name

Ahmed

MiddleName

-

Affiliation

Pharmacology Department, National Research Centre

Email

ahmedfathi551@ymail.com

City

Cairo

Orcid

-

First Name

Ezzel-Din

Last Name

El-Khrisy

MiddleName

-

Affiliation

Natural Compounds Chemistry, National Research Centre

Email

ezzeldin083@gmail.com

City

-

Orcid

-

Volume

66

Article Issue

6

Related Issue

41553

Issue Date

2023-06-01

Receive Date

2022-12-06

Publish Date

2023-06-01

Page Start

411

Page End

418

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 66_Issue 6_Pages 411-418.pdf

PDF . 668.0kB

Link

https://ejchem.journals.ekb.eg/article_275921.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=275921

Order

41

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

New Glycosylated Flavone and Anthraquinone from Cassia notabilis Randell.: Antidiabetic, Anti-inflammatory and Analgesic Activity Evaluation

Details

Type

Article

Created At

30 Dec 2024