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258109

Synthesis, characterization, potential anticancer activity, and molecular docking studies of Fe(II)Prolinedithiocarbamate complex on MCF-7 breast cancer cell lines

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Last updated: 01 Jan 2025

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Abstract

A new complex compound of Fe(II)Prolinedithiocarbamate has been synthesized, characterized, and was tested for MCF-7 cell in vitro and in silico with molecular docking studies. Characterized tests such as melting point, conductivity, UV-Vis spectroscopy, and FT-IR spectroscopy have been performed. The in vitro test results showed morphological changes (apoptosis) in MCF-7 cancer cells start at 75 μg/ml. The molecular docking study of the complex Fe(II)Prolinedithiocarbamate was identified with O(6)-methylguanine-DNA methyltransferase (MGMT) protein. Fe(II)Prolinedithiocarbamate - O(6)-methylguanine-DNA methyltransferase (MGMT) showed the active site with amino acid residues GLU77, LEU142, ILE76, dan TRP65. The hydrogen and hydrophobic bond were seen in Fe(II)Prolinedithiocarbamate - O(6)-methylguanine-DNA methyltransferase (MGMT) has a binding energy -183.25 kJ/mol. According in vitro test and molecular docking study, this compound has a potential anticancer activity.

DOI

10.21608/ejchem.2022.149508.6466

Keywords

complex, Cytotoxicity, MCF-7 cell lines, breast cancer, Anticancer activity, Dithiocarbamate

Authors

First Name

Sulistiani

Last Name

Jarre

MiddleName

-

Affiliation

Department of Chemistry, Hasanuddin University

Email

sulistiani.jarre@yahoo.com

City

-

Orcid

-

First Name

Indah

Last Name

Raya

MiddleName

-

Affiliation

Chemistry Department, Hasanuddin University

Email

indahraya05@gmail.com

City

Makassar

Orcid

0000-0001-8575-1994

First Name

Prihantono

Last Name

Prihantono

MiddleName

-

Affiliation

Department of Oncology, Medicine Faculty, Hasanuddin University, Perintis Kemerdekaan Street Km. 10 Tamalanrea, Makassar 90245, Indonesia

Email

prihantono.md@gmail.com

City

Makassar

Orcid

0000-0002-8247-0457

First Name

Rugaiyah

Last Name

Arfah

MiddleName

-

Affiliation

Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Hasanuddin University, Makassar, 90245, Indonesia

Email

rugaiyaha.arfah@gmail.com

City

-

Orcid

-

First Name

Maming

Last Name

Gappa

MiddleName

-

Affiliation

Department of Chemistry, Hasanuddin University

Email

maming@science.unhas.ac.id

City

-

Orcid

-

First Name

Siti

Last Name

Fauziah

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Mathematics and Natural Science, University of Hasanuddin, Jalan. Perintis Kemerdekaan 90245, Makassar-Indonesia

Email

stfauziah_as@yahoo.co.id

City

Makassar

Orcid

-

First Name

Santi

Last Name

Santi

MiddleName

-

Affiliation

Medical Laboratory Technology, Megarezky University

Email

santi.ssi96@gmail.com

City

-

Orcid

-

First Name

Rizal

Last Name

Irfandi

MiddleName

-

Affiliation

Department of Biology Education, Faculty of Teacher Training and Education, Puangrimaggalatung University, Sengkang, Indonesia

Email

rizalirfandi043@gmail.com

City

Makassar

Orcid

0000-0002-4845-3397

Volume

66

Article Issue

6

Related Issue

41553

Issue Date

2023-06-01

Receive Date

2022-07-11

Publish Date

2023-06-01

Page Start

61

Page End

67

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 66_Issue 6_Pages 61-67.pdf

PDF . 511.3kB

Link

https://ejchem.journals.ekb.eg/article_258109.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=258109

Order

6

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Synthesis, characterization, potential anticancer activity, and molecular docking studies of Fe(II)Prolinedithiocarbamate complex on MCF-7 breast cancer cell lines

Details

Type

Article

Created At

30 Dec 2024