N-Acetylcysteine (NAC) is an antioxidant compound with antitumor properties. In this study NAC was encapsulated into niosomes for treatment tumor in mice. NAC- encapsulated niosomes' morphology and Fourier-transform infrared spectroscopy (FTIR) analysis were measured. Fifteen mice male BALB/c were divided to three groups: group1: negative control, group2 positive control (tumor group), group3 treated with NAC- encapsulated niosomes after tumor growth. The effect of NAC- encapsulated niosomes on the tumor was determined by measuring tumor size progress, comet assay, oxidative stress parameters (GSH, Nitric Oxide, histopathological investigation.
Transmission electron microscopy examination found that NAC- encapsulated niosomes have spherical shape.
Tissues histological studies emphasized the protective effect of NAC- encapsulated niosomes against tumor. In conclusion oral delivery of NAC- encapsulated niosomes improved antitumor effect.