Bottle gourd; Lagenaria siceraria (LS) has been recognized as the most popular and widely used fruits vegetable due to its immense health-promoting properties. As a continuation of our ongoing research on the chemical composition of the fresh and dry fruits, seeds and leaves of L. siceraria cultivated in Egypt, namely, the moisture, ash, pH, total solids, antioxidants, proteins, phenolics, flavonoids, tannins, reducing and non-reducing sugars, carbohydrates, B vitamins (B1, B2, B6, B9, and B12), and vitamins (C, A, D, E and K) were determined intensively. Biologically, the insecticidal properties of the different plant's parts were explored against the mosquito, Culex pipiens larvae and adults. Tested materials showed larvicidal activity in particular fresh/roasted seeds and leaves extracts with LC50 concentrations in the range of 12.015-16.166 ppm. Fecundity and egg-hatchability percentages were significantly reduced when LC50 and LC90 concentrations applied. Additionally, tested extracts reduced fecundity to > 6 folds when LC90 concentration was applied. Repellency test elucidated that fruits and fresh seeds extracts behave like strong repellents either when LC50 (>85%) or LC90 (>90%) was applied. Overall, the obtained data provide detailed analysis to the chemical composition of L. siceraria cultivated in Egypt and highlight the insecticidal potential of different plant-part extracts as an effective and safe agent.