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276341

Pyrimidine hydrazide ligand and its metal complexes: synthesis, ‎characterization, and antimicrobial activities

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Last updated: 01 Jan 2025

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Abstract

Increasing the resistance to current antimicrobial agents has posed a pressing need for the development ‎of new antimicrobial agents. We, therefore, benefit from the antimicrobial characteristics of pyrimidine ‎derivatives to prepare a new 4-(4-bromophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-‎carbohydrazide ligand. The ligand complexes of (3d; Cr, Mn, Fe, Co, Ni, Cu, and Zn) and 4d -Cd metals ‎are also prepared and characterized by different techniques. The ligand acts as a neutral bidentate and ‎exhibited octahedral geometry. In vitro antibacterial activity of the ligand and its complexes against ‎Staphylococcus aureus and Escherichia coli was investigated. Also, the antifungal against Candida ‎albicans and Aspergillus flavus was evaluated. The results showed that the produced complexes have ‎antibacterial activity higher than the ligand. The Cd(II) complex showed antifungal activity higher than ‎the other complexes.‎

DOI

10.21608/ejchem.2022.173181.7161

Keywords

Pyrimidine, Hydrazide, Metal complexes, antimicrobial.‎

Authors

First Name

S.

Last Name

Saeed

MiddleName

El-Sayed

Affiliation

Department of Chemistry, College of Science, Qassim University, Saudi Arabia.

Email

s.saeed@qu.edu.sa

City

-

Orcid

‎0000-0002-0532-6208

First Name

Budoor

Last Name

Alomari

MiddleName

A.

Affiliation

Department of Chemistry, College of Science, Qassim University, Saudi Arabia.

Email

bu17do@gmail.com

City

Saudi Arabis

Orcid

-

First Name

Ahmed N.

Last Name

Alhakimi

MiddleName

-

Affiliation

Department of Chemistry, College of Science, Qassim University, Saudi Arabia., Department of Chemistry, College of Science, Ibb University, Ibb, Yemen

Email

alhakemi10@yahoo.com

City

-

Orcid

‎0000-0002-5141-9333

First Name

M.

Last Name

Abd El-Hady

MiddleName

M.

Affiliation

Department of Chemistry, College of Science, Qassim University, Saudi Arabia., National Research Centre (Scopus affiliation ID: 60014618), Institute of Textile Research and Technology, Dokki, Giza 12622, Egypt.

Email

m.aish@qu.edu.sa

City

Saudi Arabia.‎

Orcid

‎0000-0002-8451-8960

First Name

Jawza

Last Name

Alnawmasi

MiddleName

Sh

Affiliation

Department of Chemistry, College of Science, Qassim University, Saudi Arabia.

Email

jnomsy@qu.edu.sa

City

Saudi Arabia.‎

Orcid

-

First Name

Hussein

Last Name

Elganzory

MiddleName

H.

Affiliation

Department of Chemistry, College of Science, Qassim University, Saudi Arabia.

Email

hhsien@qu.edu.sa

City

Buraidah

Orcid

0000-0002-9426-5434

First Name

Wael A.

Last Name

El-Sayed

MiddleName

-

Affiliation

Department of Chemistry, College of Science, Qassim University, Saudi Arabia., Photochemistry Department, National Research Centre, Dokki, Giza 12622, Egypt.

Email

w.shendy@qu.edu.sa

City

Saudi Arabia.‎

Orcid

-

Volume

66

Article Issue

5

Related Issue

41550

Issue Date

2023-05-01

Receive Date

2022-11-06

Publish Date

2023-05-01

Page Start

315

Page End

329

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 66_Issue 5_Pages 315-329.pdf

PDF . 2.1MB

Link

https://ejchem.journals.ekb.eg/article_276341.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=276341

Order

276,341

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Pyrimidine hydrazide ligand and its metal complexes: synthesis, ‎characterization, and antimicrobial activities

Details

Type

Article

Created At

30 Dec 2024