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293677

From Synthesis to Biological Impact of Ru (II) Complexes: Preparation, Characterization, Antimicrobial, Antioxidant scavenging and Enzymatic inhibitory activities

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Last updated: 01 Jan 2025

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Tags

Organic chemistry

Abstract

The reaction of [RuCl2(p-cymene)]2 with in situ prepared Ag-N-heterocyclic carbene (NHC) complexes yields a series of [RuCl2(p-cymene) (NHC)] complexes 3. The structures of complexes were established by appropriate spectroscopic methods and elemental analyses. The biological activities of the synthesized ligands and their Ru (II) complexes as acetylcholinesterase, antimicrobial, and antioxidant agents were evaluated. The lowest MICs values were obtained with the two complexes 3b and 3d. The enzymatic inhibitory investigation against acetylcholinesterase (AChE) and tyrosinase (TyrE), showed that the two complexes 3b and 3d are the most potent inhibitors against (AchE) with an IC50 of 2.52 and 5.06 µg mL-1 respectively, and against (TyrE) with an IC50 of 19.88 and 24.95 µg mL-1 respectively. Additionally, DPPH (2,2-diphenyl-1-picrylhydrazyl) has been tested for its ability to scavenge hydrogen peroxide and free radicals. According to our results, these compounds exhibit excellent radical scavenging properties

DOI

10.21608/ejchem.2023.122780.5495

Keywords

: Biological activity, N-Heterocyclic carbene, benzimidazolium salts, ruthenium complexes, silver complexes

Authors

First Name

Nasser

Last Name

Amri

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Jazan University, P.O. Box 2097, Jazan 45142; Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Yousef E.

Last Name

Mukhrish

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Jazan University, P.O. Box 2097, Jazan 45142; Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Rafik

Last Name

Gatri

MiddleName

-

Affiliation

Laboratoire de Synthèse Organique Sélective et Hétérocyclique Évaluation Biologique LR17ES01 Faculté des Sciences de Tunis Faculté des Sciences de Tunis Campus Universitaire 1092 Tunis, Tunisie, Université de Tunis El Manar

Email

-

City

-

Orcid

-

First Name

Nevin

Last Name

Gürbüz

MiddleName

-

Affiliation

İnönü University, Catalysis Research and Application Center, 44280-Malatya, Turkey, İnönü University, Faculty of Science and Art, Department of Chemistry, 44280 Malatya, Turkey

Email

-

City

-

Orcid

-

First Name

Ismail

Last Name

Özdemir

MiddleName

-

Affiliation

İnönü University, Catalysis Research and Application Center, 44280-Malatya, Turkey, İnönü University, Faculty of Science and Art, Department of Chemistry, 44280 Malatya, Turkey

Email

-

City

-

Orcid

-

First Name

Khaireddine

Last Name

Dridi

MiddleName

-

Affiliation

Department of Chemistry, College of Science and Arts at Ar Rass, Qassim University, Ar Rass, 51452, Saudi Arabia

Email

khairydridi@yahoo.fr

City

-

Orcid

-

First Name

Naceur

Last Name

Hamdi

MiddleName

-

Affiliation

Department of Chemistry, College of Science and Arts at Ar Rass, Qassim University, Ar Rass, 51452, Saudi Arabia

Email

hamdi_naceur@yahoo.fr

City

denden

Orcid

-

Volume

66

Article Issue

5

Related Issue

41550

Issue Date

2023-05-01

Receive Date

2022-02-19

Publish Date

2023-05-01

Page Start

203

Page End

214

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 66_Issue 5_Pages 203-214.pdf

PDF . 1.1MB

Link

https://ejchem.journals.ekb.eg/article_293677.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=293677

Order

293,677

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

From Synthesis to Biological Impact of Ru (II) Complexes: Preparation, Characterization, Antimicrobial, Antioxidant scavenging and Enzymatic inhibitory activities

Details

Type

Article

Created At

30 Dec 2024