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255336

Study of the Midkine level and its Correlation with toxic and Essential Metals in Patients with Atherosclerosis

Article

Last updated: 01 Jan 2025

Subjects

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Tags

Biochemistry

Abstract

Abstract

The research includes studying of level for midkine (MK), toxic metals (TMs) (Including: Arsenic(As), Mercury(Hg), Cadmium(Cd)) and essential metals (EMs) (Including: Magnesium(Mg), Calcium (Ca), Iron(Fe)) in serum for atherosclerosis patients (APs). The study was done in Mosul city on (107) samples, including 57 for APs and 50 who were healthy as a control group.

The results showed a significant increase in MK, As, Hg and Cd levels for all studied (All, males and females) groups compared with control groups. While, the results of measurements of EMs indicated that there was a significant decrease in Ca, Mg and Fe compared with control groups and this indicates the effect of atherosclerosis.

The study indicated that the MK increased in patients with atherosclerosis, and it increased in males more than in female patients, in addition, to increase in TMs measured (As, Hg and Cd) helped increase the pathogenesis of atherosclerosis by increasing the level of MK and decreasing levels of Ca, Mg and Fe. Thus, increasing the intake of nutritional supplements from essential minerals is important in reducing the severity of infection. And that MK can be considered a good indicator of the occurrence of atherosclerosis.

DOI

10.21608/ejchem.2022.148718.6427

Keywords

Keywords: Atherosclerosis, Midkine, Arsenic, mercury, cadmium, essential metals

Authors

First Name

Obeda A.

Last Name

Al-Kado

MiddleName

-

Affiliation

Directorate of Education in Nineveh /Mosul, Iraq

Email

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City

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Orcid

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First Name

Luay A.

Last Name

Al-Helaly

MiddleName

-

Affiliation

Chemistry department, College of science, University of Mosul, Mosul, Iraq

Email

-

City

-

Orcid

-

Volume

66

Article Issue

5

Related Issue

41550

Issue Date

2023-05-01

Receive Date

2022-07-03

Publish Date

2023-05-01

Page Start

161

Page End

167

Print ISSN

0449-2285

Online ISSN

2357-0245

Link

https://ejchem.journals.ekb.eg/article_255336.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=255336

Order

255,336

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Study of the Midkine level and its Correlation with toxic and Essential Metals in Patients with Atherosclerosis

Details

Type

Article

Created At

30 Dec 2024