The present study tried to evaluate the anticancer ability of curcumin by decreasing its adverse effects and increasing its bioavailability. In this work curcumin was loaded in nano emulsions then characterized by transmission electron microscope (TEM). The antitumor efficacy of the curcumin nano emulsions was assessed in mice by DNA comet assay analysis, FTIR and examination of tumor histopathology. The obtained results found that mice treated with curcumin nano emulsions were effective in reducing DNA damage and changes in tumor tissue structure. In conclusion, curcumin nano emulsions have potential efficiency in treating tumor tissues.