Background: CinnamomumzeylanicumNees (Lauraceae) is used as a spicy culinary herb in the conventional eastern region. Cinnamon bark is a rich part in phytochemical compounds, bioactive phenolic compounds, and vitamins that are constituted a therapeutic chemical composition. The extract of cinnamon bark was identified as a potent source of antioxidants, and anti-inflammatory compounds. Aim: detection of the qualitative and quantitative various antioxidant compounds from C.zeylanicum barks using classical extraction and HPLC methods. Methodology: the preparation of water and ethanol extract Cinnamon bark powder at a ratio of (1:10). Different experimental methods have been used to indicate phytochemical constituents in cinnamon water extract using various chemical reagents. HPLC method was used to quantify the phenols and vitamins in cinnamon extract bark. Results: the qualitative detection of phytochemical compounds in cinnamon water extract showed the presence of saponins, steroids, alkaloids, phenols, tannins, flavonoids, coumarins, and resins. Quantification detection of trace elements (Zn,Se, Cu, Fe, Mn, Co, V, Ni, and Mo) helpskeep oxidative/antioxidant balance in mammalianorganisms.The present study investigated the roll of cinnamaldehyde and eugenolas a major phenolic compounds that may be responsible for the observed antioxidant activity in water extract of cinnamon bark.The result showed a variety of phenolic compounds (quercetin, gallic acid, rutin, kaempferol, lignin, and pyrogallol) that have an antioxidant activity and anti-inflammatory effect in different mechanisms. Vitamins gave an interesting results by the indicated concentration of fat-soluble vitamins (A, E, D, K) and water-soluble vitamins (C, B1, B2) in water extract and ethanol extract of bark. Conclusion: Cinnamomumzeylanicum bark has bioactive compounds responsible for antioxidant, antidiabetic, and anti-inflammatory activities. Therefore, it can be considered a traditional medical plant to prevent disease, and further investigations for more cinnamon properties should be conducted on this abundant plant which acts as a natural source of alternative medical drugs.